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Improved Field Biosensor for Organophosphates

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: DAMD17-02-C-0090
Agency Tracking Number: C021-0117
Amount: $730,000.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2003
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
c/o Anthrogenesis Corporation, 45 Horsehill Road, Cedar Knolls, NJ, 07927
DUNS: 057091063
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Bernard Green
 President/CSO
 (877) 275-1899
 green@semorex.com
Business Contact
 Morris Priwler
Title: CEO
Phone: (877) 275-1899
Email: priwler@semorex.com
Research Institution
N/A
Abstract
Semorex has carried out a successful Phase I project which demonstrates the potential of Molecularly Imprinted Polymer (MIP) technology to solve the critical problem of improving organophosphate (OP) detection. MIPs, plastic polymers with specificmolecular binding sites molded into them, combine the selectivity of antibodies with the robustness of polymers.Prior to and as part of Phase I, Semorex has designed and prepared MIPs capable of covalently binding and neutralizing OP-model compounds. These MIPs displayed: 1) affinity binding constants similar to antibodies; 2) thermal stability unimaginable inbiological systems; 3) agent selectivity; 4) rapid binding at low concentrations; 5) no leakage of receptor sites; and 6) suitability for sensor application. Indeed, during Phase I Semorex met or exceeded all project goals and clearly demonstrated thefeasibility of preparing MIPs that effectively bind and selectively detect OP nerve agent analogs in air and water. We also demonstrated that MIPs could be incorporated as rapid, selective detection components of sensor systems.The major objectives of the continuation (

* Information listed above is at the time of submission. *

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