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Fluorescent Coated Filters for the Detection of Biological Warfare Agents in Water

Award Information
Agency: Department of Defense
Branch: Army
Contract: DAAD19-02-C-0084
Agency Tracking Number: 44189-CH
Amount: $100,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
200 Turnpike Road
Chelmsford, MA 01824
United States
DUNS: 021977843
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Senerath Palamakumbura
 Sensor Scientist
 (978) 606-2600
Business Contact
 Hamed Borhanian
Title: President
Phone: (978) 606-2600
Research Institution
 University of Central Florida
 Griselle Baez-Munoz
4000 Central Florida Blvd
Orlando, FL 32826
United States

 (407) 823-5173
 Nonprofit College or University

Sensera, Inc., in collaboration with U. of Central Florida, proposes to develop a rapid real-time sensor for fluorescent detection of Biological Warfare Agent (BWA) micro-organisms in water. The proposed sensor does not require the additional steps oftypical heterogeneous immunoassays such as: multiple reagent additions, incubation, and washing steps. We propose two biomimetic coating platforms with their own distinctive advantages for pre-concentrating BWAs, as well as providing an environmentconducive to bio-recognition. These platforms are such that their physicochemical properties can be easily and systematically tuned for optimum binding and signal generation. Commercial fluorophores - as well as fluorophores developed in our laboratories -that possess much higher photo-stabilities and fluorescence quantum yields will be used as probes. The resulting sensors will feature reduced leaching of the probe into the biological medium, alleviating toxicity and contamination concerns, and assuringintimate interaction between the BWAs and the probes. In Phase I, we will develop a fluorescent polymerized biomimetic filter coating for the detection of a model BWA simulant. Phase II will be devoted to developing this membrane platform for thedetection of multiple BWAs, designing and constructing the fluidics hardware, and the complete characterization of the resulting sensors. The proposed rapid biosensor will find commercial application in real-time monitoring of water reservoirs, livestockand crops. Other commercial applications include: food-quality monitoring and sensors for the personal security industry.

* Information listed above is at the time of submission. *

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