RADIAL FLOW BIOREACTOR FOR ANCHORAGE-DEPENDENT CELLS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 7294
Amount: $49,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Po Box 5155, Hercules, CA, 94547
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 BARRY D SCHWARTZ PHD
 (415) 724-5400
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE PURPOSE OF THE RESEARCH IS TO DEVELOP A CELL-CULTURE GROWTH CHAMBER FOR ANCHORAGE-DEPENDENT CELLS THAT IS CAPABLEOF ACHIEVING HIGH CELL DENSITIES AND CAN BE EASILY SCALED UP. SUCH A CHAMBER CAN BE USED FOR THE ECONOMICAL PRODUCTION OF A NUMBER OF IMPORTANT THERAPEUTIC AND DIAGNOSTIC SUBSTANCES THAT CANNOT BE PRODUCED FROM ANIMAL TISSUE OR BACTERIAL SYSTEMS. THE CULTURE CHAMBER WILL BE DESIGNED SO THAT THERE IS A TRANSVERSE FLOW OF CULTURE MEDIUM ACROSS A PACKED BED OF MICROCARRIERS WITH ATTACHED CELLS. A UNIQUE DESIGN, BASED ON RADIAL FLOW DYNAMICS, SHOULD MINIMIZE THE NONOPTIMAL CULTURE-PERFUSION PROBLEMS THAT ARE CHARACTERISTIC OF OTHER LARGE-SCALE CULTURE METHODSAND SHOULD MAXIMIZE THE UNIFORMITY OF MEDIUM DELIVERY AND CELL VIABILITY. BECAUSE ANCHORAGE-DEPENDENT CELLS ARE BECOMING INCREASINGLY IMPORTANT FOR THE PRODUCTION OF VALUABLE BIOMOLECULES, AND BECAUSE THE COMPETITIVE CELL-GROWTH TECHNOLOGIES THAT EXIST SUFFER FROM A NUMBER OF PITFALLS, THERE APPEARS TO BE CONSIDERABLE APPLICATION FOR THIS RESEARCH.

* Information listed above is at the time of submission. *

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