RADIAL FLOW BIOREACTOR FOR ANCHORAGE-DEPENDENT CELLS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7294
Agency Tracking Number:
7294
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Po Box 5155, Hercules, CA, 94547
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
BARRY D SCHWARTZ PHD
(415) 724-5400
Business Contact:
() -
Research Institution:
n/a
Abstract
THE PURPOSE OF THE RESEARCH IS TO DEVELOP A CELL-CULTURE GROWTH CHAMBER FOR ANCHORAGE-DEPENDENT CELLS THAT IS CAPABLEOF ACHIEVING HIGH CELL DENSITIES AND CAN BE EASILY SCALED UP. SUCH A CHAMBER CAN BE USED FOR THE ECONOMICAL PRODUCTION OF A NUMBER OF IMPORTANT THERAPEUTIC AND DIAGNOSTIC SUBSTANCES THAT CANNOT BE PRODUCED FROM ANIMAL TISSUE OR BACTERIAL SYSTEMS. THE CULTURE CHAMBER WILL BE DESIGNED SO THAT THERE IS A TRANSVERSE FLOW OF CULTURE MEDIUM ACROSS A PACKED BED OF MICROCARRIERS WITH ATTACHED CELLS. A UNIQUE DESIGN, BASED ON RADIAL FLOW DYNAMICS, SHOULD MINIMIZE THE NONOPTIMAL CULTURE-PERFUSION PROBLEMS THAT ARE CHARACTERISTIC OF OTHER LARGE-SCALE CULTURE METHODSAND SHOULD MAXIMIZE THE UNIFORMITY OF MEDIUM DELIVERY AND CELL VIABILITY. BECAUSE ANCHORAGE-DEPENDENT CELLS ARE BECOMING INCREASINGLY IMPORTANT FOR THE PRODUCTION OF VALUABLE BIOMOLECULES, AND BECAUSE THE COMPETITIVE CELL-GROWTH TECHNOLOGIES THAT EXIST SUFFER FROM A NUMBER OF PITFALLS, THERE APPEARS TO BE CONSIDERABLE APPLICATION FOR THIS RESEARCH.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government