SHIKIMATE ENZYMES AS NOVEL TUBERCULOSIS DRUG TARGETS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 1R43AI046094-01
Amount: $294,182.00
Phase: Phase I
Program: SBIR
Awards Year: 1999
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
SEQUELLA, INC.
9610 MEDICAL CENTER DR, STE 200, ROCKVILLE, MD, 20850
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 JAN DIJKSTRA
 () -
Business Contact
Phone: (301) 762-7776
Email: CAROLNACY@SEQUELLA.COM
Research Institution
N/A
Abstract
Not Available The development of equipment that requires extensive fluid manipulation, such as analytical diagnostic tools, has generally lagged behind those of a purely electromechanical nature, even though obvious demand exists in areas as diverse as medicine, environmental monitoring, food safety, and counter-terrorism. We propose a self-contained, miniaturized bioassay system that is capable of simultaneously detecting and quantifying the presence of 6 to 10 analytes in a single sample of less than 500 microliters volume. Such a diagnostic device has clear applicability to many industrial, medical and military sectors. This handheld, multi-analyte, wet-chemistry diagnostic system will measure diverse water-borne analytes at concentrations ranging to below one part per billion. The system will be constructed by the integration of state-of-the-art digital and analog circuitry with novel miniaturized fluid handling technologies, optics, and highly specific antibody-based assay techniques. All analyte-specific assay components will be incorporated in a disposable molded plastic coupon, allowing the system to detect and quantify a wide range of chemicals, proteins, viruses, bacteria and biological fragments by simply changing coupons. The proposed system allows coupon re-use until a strong positive showing occurs, greatly reducing costs in applications such as counter-terrorism where most measurements will produce negative responses. BENEFITS: Environmental, medical and public safe

* information listed above is at the time of submission.

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