High-Throughput Brain Injury Proteomic Microassay

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-05-C-0172
Agency Tracking Number: O054-003-2024
Amount: $100,000.00
Phase: Phase I
Program: STTR
Awards Year: 2005
Solicitation Year: 2005
Solicitation Topic Code: OSD05-T003
Solicitation Number: N/A
Small Business Information
535 W. Research Blvd., Suite 135, M/S 400, Fayetteville, AR, 72701
DUNS: 125518428
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Prabhu Arumugam
 Senior Engineer
 (479) 571-2592
Business Contact
 Mark Wagstaff
Title: Vice President
Phone: (479) 571-2592
Email: mwagstaff@virtual-incubation.com
Research Institution
 Rosemary Ruff
 Research and Sponsored Program, 120 Ozark Hall
Fayetteville, AR, 72701
 (479) 575-3845
 Nonprofit college or university
SFC Fluidics in coordination with the University of Arkansas proposes to develop an immunoassay based lab-on-a-chip using the advantages of self-contained microelectrochemical detection and redox magnetohydrodynamic (MHD) microfluidics for the rapid detection of biomarkers of traumatic brain injury (TBI) from a pinprick sample of blood. The disposable cartridge will contain all of the reagents necessary to complete the assay and will move the components of the assay along preprogrammed paths. All that the user will need to do is inject a known quantity of blood serum from a patient, push a button and wait ~30 min for a digital readout of results. The instrument will be designed to be sturdy and compact as would be necessary for diagnosing a soldier in the field. In Phase I we will demonstrate the microelectrochemical-based assay platform to simultaneously detect two TBI biomarkers in blood serum for which monoclonal antibodies are commercially available. Phase I will also focus on the manipulation of the immunoassay components in a redox magnetohydrodynamic (MHD) based microfluidic network to show feasibility. This microelectrochemical assay/MHD microfluidic cartridge can be expanded later in Phase II to incorporate many other biomarkers for TBI and allow for portability and complete automation.

* Information listed above is at the time of submission. *

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