STTR Phase II: Magnetohydrodynamic-based Circular Liquid Chromatography

Award Information
Agency:
National Science Foundation
Amount:
$500,000.00
Program:
STTR
Contract:
0822723
Solitcitation Year:
N/A
Solicitation Number:
NSF 05-605
Branch:
N/A
Award Year:
2008
Phase:
Phase II
Agency Tracking Number:
0611106
Solicitation Topic Code:
BT
Small Business Information
SFC FLUIDICS, LLC
535 W RESEARCH BLVD, SUITE 135,, FAYETTEVILLE, AR, 72701
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
125518428
Principal Investigator
 Christine Evans
 PhD
 (479) 571-2592
 ceevans@sfc-fluidics.com
Business Contact
 Christine Evans
Title: PhD
Phone: (479) 571-2592
Email: ceevans@sfc-fluidics.com
Research Institution
 University of Pennsylvania
 Haim Bau
 3451 Walnut Street
PHILADELPHIA, PA, 19104
 (215) 898-8363
 Nonprofit college or university
Abstract
This STTR Phase II research project develops a circular chemical separation system on a small (~1 inch x 1 inch) chip. This chip and the associated instrument will separate complex mixtures for biological, chemical, medical, and industrial applications. Based on magnetohydrodynamic (MHD)-driven liquid flow, liquid chromatographic (LC) separations will be accomplished in a circular, closed-loop format. Typically, LC separations require a sample containing multiple analytes to flow in a single direction along a fixed-length, linear column with detection performed after the analytes elute from the column. In the circular LC system, miniaturization is possible because samples are instead circulated around a closed-loop chromatographic column thus, the effective column length is not limited to small chip dimensions. Very few methods can provide the mobile-phase pumping in a closed-loop that is required for practical application of circular LC. The MHD-based circular LC system envisioned will be small, portable, and designed for laboratory as well as field use. The sealed LC chip will contain the stationary phase, mobile phase, and all in situ MHD pumps needed to conduct the separation of complex samples. This prototype LC instrument will be designed and fabricated with a built-in fluorescence detector for monitoring analyte separation directly on the chromatographic column. The broader impacts of this research are highlighted by the ability of the proposed circular separation system to miniaturize a valuable analytical tool, liquid chromatography (LC). Samples of interest include human blood serum, saliva, and urine, with component analytes of interest that are equally diverse (e.g. proteins, pharmaceuticals, and small molecular biomarkers). Many analytes in these complex mixtures have similar properties and cannot be separated and analyzed using a very short chromatographic column, which has limited the miniaturization of this important analytical tool. This limitation is overcome using circular LC, where the effective column length is not limited by the small chip sizes that are essential for portable LC instrumentation. SFC Fluidics' core technology makes possible the miniaturized, closed-loop pumping required for implementation. This method has broad implications for the portable LC systems for field deployment or point-of-care applications. The market opportunity is expected to be significant, particularly when considering that applicability extends beyond the traditional instrumentation market into the worldwide point-of-care diagnostics market.

* information listed above is at the time of submission.

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