LIPOSOME SIALIDATION

Award Information
Agency:
Department of Defense
Branch
Navy
Amount:
$250,000.00
Award Year:
1989
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
9094
Agency Tracking Number:
9094
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1810 Magnavox Wy, Fort Wayne, IN, 46804
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
D James Morre
(317) 494-1388
Business Contact:
() -
Research Institute:
n/a
Abstract
THIS PROPOSAL IS TO DEMONSTRATE FEASIBILITY OF INSERTION OF SIALIC ACID MOLECULES INTO MEMBRANES OF LIPOSOMES CARRYING HEMOGLOBIN. THE LIPOSOMES MAY BE PROVIDED BY NAVY CONTRACTORS OR PREPARED BY OFFEROR ACCORDING TO CONTRACTORS' SPECIFICATIONS FOR FOMULATION. THE ADDED SIALIC ACID WILL PROTECT THE LIPOSOMES FROM CLEARANCE BY THE RETICULOENDOTHELIAL SYSTEM AND THEREBY INCREASE THE RESIDENCY TIME OF THE LIPOSOMES IN THE CIRCULATION. NATURALLY-OCCURRING MOLECULES CONTAINING SIALIC ACID, CHIEFLY GANGLIOSIDES, WILL BE UTILIZED INITIALLY FOR THIS PURPOSE. THESE MOLECULES ARE OF LOW INTRINSIC ANTIGENICITY AND INTERCALATED SPONTANEOUSLY INTO LIPOSOMES WITH THE FORMATION OF STABLE ASSOCIATIONS. THE SIALIC ACID-RICH CARBOHYDRATE PORTIONS ARE DIRECTED TO THE EXTERNAL, AQUEOUS ENVIRONMENT. MODEL COMPOUNDS SUCH AS GANGLIOSIDE MINICS THAT CONTAIN SIALIC ACID OR OTHER CHARGED GROUPS WILL THEN BE DEVELOPED FOR ECONOMICAL LARGE-SCALE PRODUCTION OF NONPYROGENIC, CLEARANCE-RESISTANT LIPOSOMES CONTAINING HEMOGLOBIN THAT ARE BOTH INVISIBLE TO IMMUNE SURVEILLANCE AND THAT RETAIN FULL OXYGEN-CARRYING CAPACITY.

* information listed above is at the time of submission.

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