VEGF-Based Delivery of Boron Therapeutics

Award Information
Agency:
Department of Energy
Branch
n/a
Amount:
$99,510.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
DE-FG02-02ER83520
Agency Tracking Number:
70733S02-I
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Sibtech, Inc.
705 North Mountain Road, Newington, CT, 06111
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Joseph Backer
(860) 953-1164
jbacker@sibtech.com
Business Contact:
Joseph Backer
70733
(860) 953-1164
jbacker@sibtech.com
Research Institution:
n/a
Abstract
70733 Because the growth of primary tumor and metastatic lesions beyond a few millimeters requires formation of new blood vessels (angiogenesis), the targeted delivery of cytotoxic drugs to growing tumor blood vessels may form the basis for a highly selective anti-cancer therapy. Particularly attractive are two-step therapies that initially deliver relatively non-toxic ¿prodrugs¿ that are subsequently activated at the sites of angiogenesis. This project will develop a two-step therapy that relies on the highly targeted delivery of non-toxic boron-10 (10B) containing polymers to growing endothelial cells at the sites of angiogenesis. Upon irradiation with low-energy neutrons, 10B atoms capture them, undergo nuclear fission, and yield high-energy products that destroy cells. Phase I will construct and test in vitro nanovehicles for boron-10 delivery that are targeted by the highly specific vascular endothelial growth factor. These nanovehicles will carry a high capacity cargo module containing a polymeric carrier for boron-10. The cargo module will be non-covalently docked to a specialized ¿docking tag¿ engineered into vascular endothelial growth factor. Commercial Applications and Other Benefits as described by the awardee: Targeted boron-10 therapeutics may provide an attractive alternative to highly toxic systemic chemo- and radiotherapy of cancer.

* information listed above is at the time of submission.

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