Ultrasonic Freezing of Reproductive Materials

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 HD33593-01,
Agency Tracking Number: 29298
Amount: $80,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1995
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
4850 Walnut Grove, Alpharetta, GA, 30202
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Howard Purdum
 () -
Business Contact
Phone: () -
Research Institution
The reproductive materials of vertebrate animals, including sperm, ova, and embryos, are routinelyfrozen state by a process called cryopreservation. Currently, an essential part of the cryopreservatof chemical preservative agents to these materials to prevent cell damage during freezing. This damaformation of ice crystals within the cells. As these crystals enlarge, they rupture the cell walls aPreservative agents prevent this damage from occurring by dehydrating the cells before they are frozhowever, are also poisonous to the cells over long time periods. The goal of this project is to devebiological tissues with minimum cell damage, while avoiding the use of preservative agents. The propbased on the accepted principles of cryopreservation and cryodestruction, combined with the acceptedinteraction of ultrasound with liquids. The proposed Phase I research consists of gathering the datadevelopment of commercial technology later in Phase II. If successful, the range of commercial applitechnology includes the long term storage of all soft biological tissues that are composed mostly of

* Information listed above is at the time of submission. *

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