SOLID-STATE MAGNETIC RESONANCE IS BECOMING INCREASINGLY VALUABLE FOR ANALYZING BIOLOGICAL SAMPLES SUCH AS BONE, TOOTH, AND TUMOR TISSUES.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4895
Agency Tracking Number:
4895
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
5905 Denarles Circle, Salt Lake City, UT, 84121
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DR WARNER R WOOLFENDEN
PRINCIPAL INVESTIGATOR
(801) 581-7236
Business Contact:
() -
Research Institute:
n/a
Abstract
SOLID-STATE MAGNETIC RESONANCE IS BECOMING INCREASINGLY VALUABLE FOR ANALYZING BIOLOGICAL SAMPLES SUCH AS BONE, TOOTH, AND TUMOR TISSUES. ONE OF THIS TECHNIQUE'S LIMITA- TIONS IS ITS INHERENT LOW SENSITIVITY TO SUCH COMPLEX SAMPLES. THE MAJOR GOAL OF THIS DEVELOPMENT PROJECT IS TO DESIGN AND PRODUCE A CARBON/PROTON DOUBLY TUNED VARIABLE TEMPERATURE PROBE WITH SEVERAL ADVANCED FEATURES FOR SPECIFIC APPLICATIONS TOWARD SAMPLES SUCH AS PIGMENT GALLSTONES. THE PROBE WILL HANDLE LARGER SAMPLES WITH FEWER TANK CIRCUIT LOSSES, YIELDING MORE SENSITIVITY AT 2.3 TESLA (100 MHZ PROTON) FIELD STRENGTHS. IT WILL ALSO BE ABLE TO HANDLE LARGER PROTON POWERS FOR COMPLETE DECOUPLING OF SAMPLES CONTAINING BROADENED ANISOTROPIC CARBON-13 CHEMICAL SHIFTS-A PROBLEM OFTEN FOUND WITH BIOMEDICAL SAMPLES. THE VARIABLE TEMPERATURE CAPABILITY WILL ALLOW HIGHLY AMORPHOUS SAMPLES TO BE COOLED AND STUDIED UNDER MORECRYSTALLINE AND MORE SPECTROSCOPICALLY INFORMATIVE CONDITIONS. NMR INSTRUMENTS WITH MAGNETIC FIELDS OF 4.6 TESLA AND HIGHER REQUIRE SAMPLE SPINNING RATES OF NEAR 8 KHZAND HIGHER. THIS PROJECT WILL THUS AIM AT BUILDING A PROBE HEAD SIMILAR TO THAT DESCRIBED ABOVE THAT WILL SPIN OPTIMUM SIZED SAMPLES AT 8 KHZ.

* information listed above is at the time of submission.

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