PLASMA LIPOPROTEINS ARE PARTICLES MADE UP OF PROTEINS AND LIPIDS THAT CARRY FAT THROUGH THE BLOODSTREAM TO VARIOUS PARTS OF THE BODY.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
5001
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Southern Biotechnology Assoc
160a Oxmoor Blvd, Birmingham, AL, 35209
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
ROGER L LALLONE
PRINCIPAL INVESTIGATOR
(205) 945-1774
Business Contact:
() -
Research Institution:
n/a
Abstract
PLASMA LIPOPROTEINS ARE PARTICLES MADE UP OF PROTEINS AND LIPIDS THAT CARRY FAT THROUGH THE BLOODSTREAM TO VARIOUS PARTS OF THE BODY. EVIDENCE IS CLEAR THAT LEVELS OF THE VARIOUS TYPES OF LIPOPROTEINS (HIGH DENSITY LIPOPROTEIN (HDL), LOW DENSITY LIPOPROTEIN (LDL), INTERMEDIATE DENSITY LIPOPROTEIN (IDL), AND VERY LOW DENSITY LIPOPROTEIN (VLDL)) HAVE CONSIDERABLE INFLUENCE ON AN INDIVIDUAL'S CHANCES OF DEVELOPING ATHEROSCLEROSIS. CERTAIN LIPOPROTEINS, PARTICU- LARLY LDL, HAVE AN UNFAVORABLE INFLUENCE, WHEREAS CERTAIN OTHERS, PARTICULARLY HDL, HAVE A FAVORABLE INFLUENCE. ONE OF THE GOALS OF DRUG PREVENTION OF ATHEROSCLEROSIS IS TO LOWER LDL WHILE RAISING HDL. WHILE LDL CAN BE LOWERED SIGNIFICANTLY BY A NUMBER OF DRUGS, HDL HAS GENERALLY PROVEDREFRACTORY TO DRUG THERAPY AND IN MANY INSTANCES ACTUALLY INCREASES. IT IS THOUGHT THAT LDL SERVES TO DELIVER CHOLESTEROL TO CELLS OF THE BODY, SUCH AS ARTERY WALL CELLS WHERE BUILDUP OF CHOLESTEROL IS RESPONSIBLE FOR ATHERO- SCLEROSIS, AND THAT HDL SERVES TO REMOVE CHOLESTEROL FROM CELLS IN A PROCESS CALLED REVERSE CHOLESTEROL TRANSPORT. THE PROTECTIVE EFFECT OF HDL AND ITS REVERSE CHOLESTEROL TRANSPORT ACTIVITY APPEAR TO BE TIED TO THE LEVEL OF LCAT ACTIVATION OF APOLIPOPROTEIN A-I IN HDL. SOUTHERN BIOTECH- NOLOGY ASSOCIATES PROPOSES THAT SYNTHETIC ANALOGS OF THE AMPHIPATHIC PEPTIDES CAN BE USED TO INCREASE REVERSE CHOLESTEROL TRANSPORT BY RAISING OR SUPPLEMENTING HDL VIA PEPTIDE INJECTION INTO THE BLOOD STREAM. THIS INCREASE IN REVERSE CHOLESTEROL TRANSPORT MAY SERVE TO PREVENT OR REVERSE ATHEROSCLEROSIS IN PATIENTS AT HIGH RISK.

* information listed above is at the time of submission.

Agency Micro-sites

US Flag An Official Website of the United States Government