Hadamard Transform Time-of-Flight Mass Spectrometry

Award Information
Agency:
Department of Defense
Branch
Air Force
Amount:
$100,000.00
Award Year:
2003
Program:
STTR
Phase:
Phase I
Contract:
F49620-03-C-0074
Agency Tracking Number:
F033-0151
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Southwest Sciences, Inc.
1570 Pacheco Street, Suite E-11, Santa Fe, NM, 87505
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
153579891
Principal Investigator:
Steven Massick
Senior Research Scientist
(505) 984-1322
smassick@swsciences.com
Business Contact:
Alan Stanton
President
(505) 984-1322
astanton@swsciences.com
Research Institution:
INDIANA UNIV.
David E Clemmer
Department of Chemistry, Chemistry Building Room C121
Bloomington, IN, 47405
(812) 855-8259
Nonprofit college or university
Abstract
This STTR program will develop a two-dimensional Hadamard transform method for combining time-of-flight mass spectrometry (TOFMS) and ion mobility separation (IMS) analysis of trace species. Target applications include chemical and biological agentdetection as well as protein sequencing and identification. The work builds on previous research by the Clemmer group that shows the usefulness of IMS with TOFMS for protein analysis and on Southwest Sciences' expertise in the development of compact,automated instrumentation for trace chemical detection. We anticipate that the Hadamard transform approach will improve sensitivity by increasing sample throughput, yet requires only minimal modification to the existing hardware. In Phase I we will 1)modify the existing IMS-TOFMS for Hadamard transform modulation of the TOFMS section, 2) experimentally determine the limits to mass resolution, sensitivity, and throughput for the modified instrument, and 3) investigate customized modulation waveformsthat can provide selective ion bandpass and/or notch filtering. The Phase I research will provide the critical design information needed to develop a fully two-dimensional, Hadamard transform IMSTOFMS instrument in Phase II. Applications includeproteomics, and chemical and biological agent detection.

* information listed above is at the time of submission.

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