Robotic Bioreactor for Cell Culture in Space Applications (DYNACULT)

Award Information
Agency:
National Aeronautics and Space Administration
Branch
n/a
Amount:
$0.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
NAS9-02017
Agency Tracking Number:
000765
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Space Hardware Optimization Technology
7200 Highway 150, Greenville, IN, 47124
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Paul Todd
Principal Investigator
(812) 923-9591
ptodd@shot.com
Business Contact:
Mark Deuser
President & CEO
(812) 923-9591
mdeuser@shot.com
Research Institution:
n/a
Abstract
The specific innovation proposed is a fully-automated perfused cell-culture bioreactor system (laboratory in a cassette) tentatively named DYNACULT. Space Hardware Optimization Technology, Inc.,will incorporate several technical innovations into the integrated DYNACULT system. These include, but are not limited to, options for gentle mixing of cell and/or microcarrier suspensions independently variable perfusion and oxygenation rates, pH and oxygen monitoring, real-time imaging of cells, compact design, computerized and automated control of all functions, user-friendly operation, and flexible options for automated collection of samples of cells and cell-free media simultaneously at chosen times. These functions can control and operate a 50 mL or 100 mL prototype bioreactor for several days without operator intervention. The need for these technical innovations were identified in SHOT's previous research that led to a flight-qualified and flight-proven bioreactor prototype named CELLCULT. The DYNACULT system will fit conveniently into a cassette with a volume less than 2.0 L (space-flight version) or on a single shelf of a standard tissue culture incubator. SHOT, Inc. has manufactured prototypical space cell culture devices of the DYNACULT type and will utilize this experience along with the proposed innovations to establish a position in space and biotechnology markets for fully automated cell culture instruments.

* information listed above is at the time of submission.

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