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Objective measures of speech post-L-dopa & STN DBS in PD

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41NS047959-01
Agency Tracking Number: NS047959
Amount: $380,053.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2004
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
SPEECH TECHNOLOGY AND APPLIED RESEARCH CORPORATION
BEDFORD, MA 01370
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 CRAIG VANHORNE
 (617) 732-8891
 CVANHORNE@PARTNERS.ORG
Business Contact
 JOEL MACAUSLAN
Phone: (781) 861-7827
Email: JoelM@S-T-A-R-corp.com
Research Institution
 BRIGHAM AND WOMEN'S HOSPITAL
 
RESEARCH ADMINISTRATION
BEDFORD, MA 02115
United States

 Domestic Nonprofit Research Organization
Abstract

DESCRIPTION (provided by applicant): Speech is a complex motor behavior often disrupted by neurologic dysfunction. Parkinson's disease (PD) is one of the most prominent neurological disorders associated with speech disturbances. L-dopa continues to be the cornerstone of medical treatment for the motor symptoms and typically produces some improvement of speech symptoms. As the disease progresses, medical management becomes increasingly difficult and is associated with disabling side effects. Recently, deep brain stimulation (DBS) has been shown to be an effective adjunct therapy for control of the motor symptoms in select patients with advanced disease. The clinical effects of L-dopa and DBS on speech have not been consistent, and some studies report a substantial worsening of speech following these procedures. Many of the difficulties in evaluating speech arise from the subjective nature of evaluation. Even standardized protocols administered by trained professionals demonstrate significant inter-rater variability. We propose to develop a cost effective, portable, stand-alone technology package to analyze multiple components of recorded speech. We will study the applied technology in PD patients and analyze the effects of L-dopa and DBS on objective measures of speech. We will also expand our speech assessment technologies by adding new analytical tools based on sensitive, non-linear dynamic algorithms.

* Information listed above is at the time of submission. *

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