LOW FRICTION, BACTERICIDAL SILVER COATED CATHETERS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$499,886.00
Award Year:
1993
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
16704
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Spire Corp.
One Patriots Park, Bedford, MA, 01730
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Sioshansi, Piran
Principal Investigator
(617) 275-6000
Business Contact:
1 R43 HL46097-01
() -
Research Institution:
n/a
Abstract
CATHETERS WHICH ARE CURRENTLY PRODUCED HAVE A TACKY SURFACE WHICH MAKES INSERTION DIFFICULT AND CAN RESULT IN A NUMBER OF COMPLICATIONS. THE PHASE I RESEARCH PROJECT WILL DEVELOP A SILVER COATING WHICH CAN BE DEPOSITED ON THE CATHETER TO TRANSFORM THE TACKY SURFACE INTO A LUBRICOUS, LOW FRICTION ONE. THE PARTICULAR EMPHASIS DURING THE RESEARCH WILL BE ON ANGIOPLASTY (PTCA) CATHETERS. THE COATING WILL BE APPLIED BY THE ION BEAM ASSISTED DEPOSITION (IBAD) PROCESS. IN ADDITION TO LOWERING THE FRICTION, THE COATING WILL ALSO SIGNIFICANTLY INCREASE THE TENSILE STRENGTH OF THE CATHETER AND ACT AS A BACTERICIDAL AGENT. DURING THE PHASE I RESEARCH, COATINGS WILL BE APPLIED TO POLYURETHANE COUPONS. THE COATING PROCESS WILL BE OPTIMIZED BY EVALUATING THE SAMPLES. TESTS WILL INCLUDE ADHESION, THICKNESS, AND TENSILE STRENGTH TESTS ALONG WITH EXAMINATION UNDER OPTICAL AND ELECTRON MICROSCOPY. AFTER THE COATING PROCESS HAS BEEN OPTIMIZED, PTCA CATHETERS WILL BE TREATED AND THE REDUCTION IN FRICTION MEASURED.

* information listed above is at the time of submission.

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