Elimination of Infections in External Fixation Devices

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 21942
Amount: $49,940.00
Phase: Phase I
Program: SBIR
Awards Year: 1993
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Spire Corp.
One Patriots Park, Bedford, MA, 01730
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Piran Sioshansi
 (617) 275-6000
Business Contact
Phone: () -
Research Institution
A research plan is described to establish the feasibility of using ion beam processes to reduce or eliminate pin tract infection in external fixation devices. A process will be developed for producing bacteriostatic, biocompatible surfaces. Anti-bacterial properties will be evaluated via in vitro microbial challenge tests; cytotoxicity and systemic injection tests will be used to screen biocompatibility. The in vivo efficacy of the treatment will be evaluated by treating actual pins, implanting them into tibiae of domestic sheep and comparing their performance to control pins. The pins will be retrieved and examined for bacterial colonization of several bacterial strains. These in vivo tests will lead the Phase I program into a Phase II study; Phase II will involve further analytical and bench-top testing as well as more comprehensive animal studies and/or clinical trials.

* information listed above is at the time of submission.

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