Efficacy of Thin HA Coatings Produced by a Novel Process

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$943,045.00
Award Year:
2004
Program:
SBIR
Phase:
Phase II
Contract:
2R44DE013450-02A1
Award Id:
54382
Agency Tracking Number:
1R43DE013450-01A2
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
SPIRE CORPORATION, 1 PATRIOTS PARK, BEDFORD, MA, 01730
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
ERICTOBIN
(781) 275-6000
ETOBIN@SPIRECORP.COM
Business Contact:
MARKLITTLE
(781) 275-6000
MLITTLE@SPIRECORP.COM
Research Institute:
n/a
Abstract
DESCRIPTION: (provided by the applicant) This project is developing a new generation of calcium phosphate coatings for dental implants, in which film crystallinity is optimized for enhanced bioactivity and osseointegration. Phase I examined the hypothesis that optimal crystallinity leads to more rapid and stronger device fixation. Film crystallinities ranging from 30-90% were produced by a novel, low temperature deposition method and evaluated in a small animal model (rat). It was found that the ideal range was between 50-70% crystalline. These coatings provided bone-device integration compared to conventional plasma spray coatings. The purpose of the Phase II program is to further evaluate and demonstrate the advantage of calcium phosphate coatings with optimized crystallinity, as defined in Phase I. Both early and long-term bone response will be assessed in a large animal (canine) model, both prior to and after prosthesis loading. The desire to introduce this innovative technology to the field of dental implantology is based on two primary advantages of the process over existing technology used to apply HA coatings to implants. First, the chemical composition and crystallinity of the applied coating can be precisely controlled over a wide range of values, without the need for post deposition annealing. Second, the HA coatings can be deposited at low temperature as thin films from 1 to 5 mu/m thick, much thinner than coatings applied using plasma spray technology. Thinner coatings can provide a higher interfacial strength and better resistance than thicker plasma spray coatings.

* information listed above is at the time of submission.

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