Non-invasive Blood-glucose Monitor using Terahertz Radiation

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-04-C-0109
Agency Tracking Number: O041-DH2-3050
Amount: $99,677.00
Phase: Phase I
Program: SBIR
Awards Year: 2004
Solicitation Year: 2004
Solicitation Topic Code: OSD04-DH2
Solicitation Number: 2004.1
Small Business Information
One Patriots Park, Bedford, MA, 01730
DUNS: 065137978
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Kurt Linden
 Senior Scientist
 (781) 275-6000
Business Contact
 Mark Little
Title: CEO, Spire Biomedical, In
Phone: (781) 275-6000
Research Institution
This Phase I SBIR proposal describes a research program to determine feasibility for using terahertz radiation to non-invasively monitor metabolic analytes such as glucose. Non-invasive monitoring is important for determining general physiological activity and health, and needed by diabetics for painless, rapid glucose measurement. Mid-infrared and far-infrared monitoring has been extensively explored, but after many years of research, no reliable instrument is available. Infrared glucose concentration data reliability is poor due to strong radiation scattering and overlapping signals arising from blood components that maski glucose signals. Based on published data, improved molecular discrimination may occur in the terahertz spectral region, where DNA and organic-molecule resonant absorption spectra dominate, where photon scattering is reduced, and where a new generation of miniature cascade-lasers is under development. Phase I will investigate terahertz absorption spectra in glucose-containing phantoms simulating blood, and in purchased laboratory blood solutions with known glucose concentrations. The measurements will be performed at the Brookhaven synchrotron source, using an FTIR spectrometer and terahertz radiation detector. The proposed project dovetails with a companion program to develop a miniature terahertz cascade-laser source at Spire Biomedical. Phase II will include tissue-measurements and develop a portable, non-invasive monitoring system using the terahertz cascade-laser.

* Information listed above is at the time of submission. *

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