THE OVERALL OBJECTIVE OF THIS PROJECT IS TO PRODUCE A PANEL OF POLYCLONAL (GOAT) ANTIBODIES AGAINST COLORECTAL CANCER MARKERS SUCH AS COLON SPECIFIC ANTIGEN PROTEIN (CSAP), COLON-OVARY TUMOR ANTIGEN (COTA AND CARCINOEMBRYONIC ANTIGEN (CEA) FOR THE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1984
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
1426
Agency Tracking Number:
1426
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4272 Balloon Park Road Ne, Albuquerque, NM, 87109
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
KESHAB D. PANT
DIRECTOR
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
THE OVERALL OBJECTIVE OF THIS PROJECT IS TO PRODUCE A PANEL OF POLYCLONAL (GOAT) ANTIBODIES AGAINST COLORECTAL CANCER MARKERS SUCH AS COLON SPECIFIC ANTIGEN PROTEIN (CSAP), COLON-OVARY TUMOR ANTIGEN (COTA AND CARCINOEMBRYONIC ANTIGEN (CEA) FOR THE DEVELOPMENT OF SERODIAGNOSTIC AND IMMUNOHISTOCHEMICAL REAGENTS. THESE REAGENTS WILL EVENTUALLY BE MADE INTO KITS FOR COMMERCIAL USE. PHASE I OF THIS GRANT WILL EMPHASIZE ONLY THE IMMUNOHISTOCHEMICAL APPLICATION OF THESE REAGENTS. THE IMMUNOLOGICAL APPROACH TO EARLY DETECTION AND DIAGNOSIS OF CANCER RELIES ON THE PREMISE THAT TUMOR SPECIFIC MARKERS ACHIEVE CIRCULATION IN THE BLOOD AND ARE EXPRESSED BOTH INTERNALLY AND ON THE SURFACE OF TUMORS IN CANCER PATIENTS. IMMUNODETECTION OF THESE MARKERS IN OUR LABORATORY AND OTHERS SUPPORTS THIS PREMISE. IN PHASE I, POLYCLONAL ANTIBODIES TO CSAP, COTA AND CEA WILL BE PRODUCED; THE SPECIFICITY OF THESE ANTIBODIES TO BE ENSURED BY A SERIES OF AFFINITY ADSORPTION PROCEDURES. PRELIMINARY HISTOLOGICAL TESTING OF THIS ANTIBODY PANEL WILL OCCUR IN NEW MEXICO AND IN CALIFORNIA (U.C. SAN DIEGO). IN PHASE II, PRODUCTION OF MONOCLONAL ANTIBODIES (MURINE/HUMAN) TOWARDS CSAP, COTA AND CEA WILL BEGIN AND THE F(AB')2 FRAGMENTS WILL BE PREPARED UNDER FDA GLP/GMP GUIDELINES. WHILE THESE LATER PRODUCTS MAY ALSO PROVE USEFUL AS SERODIAGNOSTICS AND IMMUNOHISTOCHEMICAL REAGENTS THEIR POSSIBLE USE IN RADIOIMMUNOIMAGING WILL BE EVALUATED.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government