THE FINAL GOAL OF THIS PROJECT IS TO PROVIDE A PRODUCT WHICH CAN BE USED PRIOR TO SURGERY TO AID THE SURGEON IN LOCALIZING PARATHYROID NEOPLASIA OR HYPERPLASIA.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,256.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
2964
Agency Tracking Number:
2964
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4272 Balloon Park Road, Albuquerque, NM, 87109
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
K. D. PANT
PRINCIPAL INVESTIGATOR
(505) 345-8891
Business Contact:
() -
Research Institute:
n/a
Abstract
THE FINAL GOAL OF THIS PROJECT IS TO PROVIDE A PRODUCT WHICH CAN BE USED PRIOR TO SURGERY TO AID THE SURGEON IN LOCALIZING PARATHYROID NEOPLASIA OR HYPERPLASIA. THE LACK OF SIMPLE, CLINICALLY USEFUL TECHNIQUES FOR PRE- OR INTRAOPERATIVE LOCALIZATION OF PARATHYROID TISSUE IS ONE OF THE MOST DIFFICULT PROBLEMS IN THE SURGICAL MANAGEMENT OF PATIENTS WITH PARATHYROID DISEASE. VARIATIONS IN THE POSITIONS OF THE PARATHYROID GLANDS IN THE NECK AND IN THE SUPERIOR MEDIASTINUM AND THE CLOSE RELATIONSHIP OF THE GLANDS TO THE RECURRENT LARYNGEAL NERVE MAKE SURGERY DIFFICULT. WE PROPOSE TO DEVELOP RADIOLABELED ANTIBODIES WHICH CAN BE USED FOR THE IN VIVO DETECTION AND LOCALIZATION OF PARATHYROID TISSUE IN PATIENTS WHO ARE CANDIDATES FOR SURGERY. IN PHASE I, WE PROPOSE TO PREPARE ANTIBODIES TO HUMAN PARATHYROID HORMONE (HPTH) AND TO DETERMINE IF THESE ANTIBODIES LOCALIZE IN PARATHYROID LESIONS OF ARCHIVED, PARAFFIN-EMBEDDED TUMOR SPECIMENS. IN PHASE II, A RADIOPHARMACEUTICAL FOR PARATHYROID IMAGING WILL BE DESIGNED UTILIZING ANTIBODIES DEFINED IN PHASE I. FURTHERMORE, WE WILL ATTEMPT TO DEVISE AN ANIMAL MODEL AND CARRY OUT PRECLINICAL TESTING.

* information listed above is at the time of submission.

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