Surface Enhanced Biocompatible Blood Oxygenators

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$127,123.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
1R43HL096196-01A1
Award Id:
96302
Agency Tracking Number:
HL096196
Solicitation Year:
n/a
Solicitation Topic Code:
NHLBI
Solicitation Number:
n/a
Small Business Information
COMPACT MEMBRANE SYSTEMS, INC., 335 WATER STREET, NEWPORT, DE, 19804
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
808898894
Principal Investigator:
DANIEL CAMPOS
() -
Business Contact:
STUART NEMSER
() -
rtierney@compactmembrane.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Compact Membrane Systems, Inc. proposes to develop novel blood oxygenator membranes with enhanced blood biocompatibility. These will be used to enhance conventional cardio bypass surgery minimizing post operative effect s. In addition, they will provide a key element for long term blood oxygenation associated with extracorporeal membrane oxygenation, acute respiratory distress syndrome, and artificial lungs. Membrane based blood oxygenators are successfully used for cardi opulmonary by-pass surgery. A number of programs are evaluating long-term membrane based blood oxygenators for artificial lungs and acute respiratory distress syndrome. For both short-term use and long-term use, there is a need for enhanced blood compatibl e surfaces. Examples of two coating systems that are presently used to enhance blood compatibility are Avecor's Trillium and Medtronic's Carmeda. While both of these systems have some success in enhancing blood compatibility, the success is limited. These systems tend to reduce gas (oxygen) flux and most importantly are prone to wetting out. Materials and devices that contact blood, such as blood tubing, dialysis membranes and blood oxygenators, require blood compatibility of the component materials. This i ncludes consideration of the protein and cellular systems of the blood. Proper control of surface chemistry can enhance biocompatibility. Compact Membrane Systems, Inc. (CMS) has significant expertise in this area. A family of non-porous membranes with exc ellent gas transport that allows the use of a non-porous membrane to provide the needed wet out resistance for long term blood oxygenation while maintaining high gas transport has been developed by CMS. These membranes will now be used as the building bloc k for enhancing biocompatibility. The net result will be a blood oxygenation membrane with the following features: gas flux comparable to micro porous polypropylene; wet out resistance of a non-porous membrane; and, excellent blood biocompatibility. This w ork will focus on enhancing the biocompatibility of blood oxygenators by controlling surface chemistry. The technology developed should allow similar developments on hemodialysis membranes and also working with polymerization of heparin to the surface of m embranes. PUBLIC HEALTH RELEVANCE: Compact Membrane Systems, Inc. proposes to develop novel blood oxygenator membranes with enhanced blood biocompatibility. These will be used to enhance conventional cardio bypass surgery minimizing post operative e ffects. In addition, they will provide a key element for long term blood oxygenation associated with extracorporeal membrane oxygenation, acute respiratory distress syndrome, and artificial lungs.

* information listed above is at the time of submission.

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