Centrifugal Cell-Retention Bioreactor

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1993
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
22086
Agency Tracking Number:
22086
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P. O. Box 5056, Hanover, NH, 03755
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Robert C. Dean Jr.
(603) 448-6322
Business Contact:
() -
Research Institute:
n/a
Abstract
In the production of large, complex therapeutic proteins, animal cells are preferred as the biocatalyst. Various types of production bioreactors are employed including deep-stirred and sparged tanks (with or without microcarriers), cell-immobilizing matrices, and fluidized beds of porous microcarriers. We have invented a new cell-retention technique using a centrifuge to remove and return living cells from the harvest to the bioreactor. According to the literature, this is a first-time achievement. Preliminary tests indicate high cell density, viability, cell-specific productivity relative to other animal-cell bioreactors. The objective of Phase I is to test this invention beyond the single cell line that has been tested in the laboratory to establish its feasibility as an economically important bioreactor for large-scale animal-cell culture in the production of therapeutic proteins. An extension of the work in Phase II will confirm its economic value at beta-sites in the biopharmaceutical industry and will extend its application to plant and insect cells. In Phase III, the centrifugal cell-retention bioreactor will be commercialized to become an important new bioprocessing tool.

* information listed above is at the time of submission.

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