Development of a Neural Co-Culture Bioactive Compound Sensor

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$99,999.00
Award Year:
2006
Program:
STTR
Phase:
Phase I
Contract:
W911NF-06-C-0093
Award Id:
78065
Agency Tracking Number:
A064-013-0249
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2021 Miller Dr., Longmont, CO, 80501
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
130993384
Principal Investigator:
ElizabethMirowski
(720) 494-8401
emirowski@synkera.com
Business Contact:
StephenWilliams
President and CTO
(720) 494-8401
swilliams@synkera.com
Research Institute:
UNIV. OF COLORADO
Randall W Draper
Office of Contracts and Grants
Boulder, CO, 80309
(303) 492-2695
Nonprofit college or university
Abstract
Synkera Technologies proposes to develop a bipartite Living Neural Networks (LNN) platform capable of sustaining two different types of intercommunicating neuronal modules that can be independently exposed to and record electrical and biochemical perturbations. The focal point of the proposed sensor will be a micromachined biochip platform for guided and reproducible growth of LNN on ceramic substrates. The advantages of this platform include the following: (1) improved growth characteristics of the neural co-culture, (2) the ability to reproducibly control neuronal and axonal outgrowth between two LNN, (3) the ability to provide discrete access of biochemical perturbations to each LNN, (4) the ability to provide nanoelectrode access with superior electrical characteristics and contact to the LNN, and (5) fewer processing steps for less expensive devices.

* information listed above is at the time of submission.

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