Development of a Neural Co-Culture Bioactive Compound Sensor

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911NF-06-C-0093
Agency Tracking Number: A064-013-0249
Amount: $99,999.00
Phase: Phase I
Program: STTR
Awards Year: 2006
Solicitation Year: 2006
Solicitation Topic Code: A06-T013
Solicitation Number: N/A
Small Business Information
2021 Miller Dr., Longmont, CO, 80501
DUNS: 130993384
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Elizabeth Mirowski
 (720) 494-8401
Business Contact
 Stephen Williams
Title: President and CTO
Phone: (720) 494-8401
Research Institution
 Randall W Draper
 Office of Contracts and Grants
Boulder, CO, 80309
 (303) 492-2695
 Nonprofit college or university
Synkera Technologies proposes to develop a bipartite Living Neural Networks (LNN) platform capable of sustaining two different types of intercommunicating neuronal modules that can be independently exposed to and record electrical and biochemical perturbations. The focal point of the proposed sensor will be a micromachined biochip platform for guided and reproducible growth of LNN on ceramic substrates. The advantages of this platform include the following: (1) improved growth characteristics of the neural co-culture, (2) the ability to reproducibly control neuronal and axonal outgrowth between two LNN, (3) the ability to provide discrete access of biochemical perturbations to each LNN, (4) the ability to provide nanoelectrode access with superior electrical characteristics and contact to the LNN, and (5) fewer processing steps for less expensive devices.

* Information listed above is at the time of submission. *

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