Nitroxide Labeled Hemoglobin as a Blood Substitute

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 HL53860-01,
Agency Tracking Number: 29514
Amount: $98,400.00
Phase: Phase I
Program: SBIR
Awards Year: 1995
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
1 Technology Drive, E-309, Irvine, CA, 92718
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Carleton Hsia
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
A number of biopharmaceutical companies have successfully taken hemoglobin-based oxygen carriers (Hinto phase I clinical trial. However, transfusions have been limited to low dosage levels due to obsvasoconstrictive effects at high dosage levels in pre-clinical animal studies. This proposal deals wfailure to have an oxidant detoxification system similar to the one which is intrinsic to the red blsubstitute. This research plan intends to modify a high- quality HBOC, which is currently in clinicathat stable nitroxide free radicals can be used to perform an oxidant detoxification function. If ththen the groundwork would established for a second generation red blood cell substitute which couldcommercialized.

* Information listed above is at the time of submission. *

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