Nitroxide Labeled Hemoglobin as a Blood Substitute

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$98,400.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 HL53860-01,
Award Id:
29514
Agency Tracking Number:
29514
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1 Technology Drive, E-309, Irvine, CA, 92718
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Carleton Hsia
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
A number of biopharmaceutical companies have successfully taken hemoglobin-based oxygen carriers (Hinto phase I clinical trial. However, transfusions have been limited to low dosage levels due to obsvasoconstrictive effects at high dosage levels in pre-clinical animal studies. This proposal deals wfailure to have an oxidant detoxification system similar to the one which is intrinsic to the red blsubstitute. This research plan intends to modify a high- quality HBOC, which is currently in clinicathat stable nitroxide free radicals can be used to perform an oxidant detoxification function. If ththen the groundwork would established for a second generation red blood cell substitute which couldcommercialized.

* information listed above is at the time of submission.

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