STATISTICAL METHODOLOGY

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4822
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Takima West Corp
100 Eastowne Drive, Suite 200, Chapel Hill, NC, 27514
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 DR NORMAN L JOHNSON
 PRINCIPAL INVESTIGATOR
 (919) 493-8574
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE TECHNICAL PROBLEM ADDRESSED BY THIS PROJECT IS THE DEVELOPMENT OF SAS-COMPATIBLE COMPUTER SOFTWARE IMPLEMENTINGADVANCED STATISTICAL METHODOLOGY. THE SPECIFIC OBJECTIVES ARE TO (1) DEVELOP SOFTWARE FOR REGRESSION DIAGNOSTICS, GOODNESS-OF-FIT ASSESSMENTS, AND MODEL VALIDATION (E.G., BOOTSTRAPPING) OF THE COX PROPORTIONAL HAZARDS AND LOGISTIC REGRESSION MODELS; (2) DEVELOP SOFTWARE TO ACCOMODATE TIME- DEPENDENT COVARIATES WITHIN THE COX MODEL; (3) EVALUATE THE BASIS FOR IMPLEMENTING COMPUTATIONAL PROCEDURES FOR RECURSIVE PARTITIONING AND DEVELOP THE PLANS FOR THIS IMPLEMENTATION; AND (4) DEVELOP THE STRUCTURE FOR SHORT COURSES TO FACILITATE SOFTWARE DISSEMINATION AND TO INSTRUCTINVESTIGATORS CONCERNING THE PROPER USE OF THESE STATISTICALAND COMPUTING TOOLS. TO ACHIEVE THESE GOALS, RESEARCHERS WILL CRITICALLY EVALUATE THE ANALYTIC TECHNIQUES CURRENTLY AVAILABLE FOR USE WITH THE LOGISTIC AND COX MODELS AND SELECT FOR IMPLEMENTATION METHODS THAT ARE STATISTICALLY EFFICIENT AND COMPUTATIONALLY PRACTICAL. THE SOFTWARE WILL BE DESIGNED TO EXTEND AND COMPLEMENT RATHER THAN DUPLICATE CONCURRENT DEVELOPMENTS BY SAS INSTITUTE. A CRITICAL APPRAISAL WILL BE COMPLETED, THE IMPORTANT TECHNICAL QUESTIONS WILL BE ADDRESSED, AND OVERALL PLANS FOR THE SOFTWARE ITSELF WILL BE DEFINED. RESULTS OF THIS PROJECT WILL ADD SIGNIFICANTLY TO THE BATTERY OF TOOLS AVAILABLE FORPROPERLY ANALYZING MEDICAL DATA.

* information listed above is at the time of submission.

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