CARCINOGENESIS INFORMATION FOR ENVIRONMENTAL SUBSTANCES

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4907
Amount: $264,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Technical Database Services In
10 Columbus Circle, Suite 2300, New York, NY, 10019
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Mildred R Green
 Principal Investigator
 (212) 245-0044
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE OBJECTIVE OF PHASE I RESEARCH IS TO ESTABLISH THE CARCINOGENESIS INFORMATION DATABASE ENVIRONMENTAL SUBSTANCES(CIDES) AS A PROTOTYPE DATABASE CONTAINING NUMERICAL PROPERTIES DATA FOR ENVIRONMENTAL SUBSTANCES WHICH ARE KNOWNOR THOUGHT TO HAVE CARCINOGENIC PROPERTIES. THE GOAL WILL BE TO PRODUCE A DATABASE WHICH INCLUDES PHYSICAL-CHEMICAL PROPERTY DATA, BOTH POSITIVE AND NEGATIVE SHORT-TERM TEST RESULTS, AND HUMAN AND ANIMAL CARCINOGENESIS DATA. A UNIQUEAIM OF THIS RESEARCH PLAN IS TO APPLY OBJECTIVE CRITERIA TO THE EXPERIMENTAL STUDIES AND DATA IN THE DATABASE IN ORDER TO DERIVE A PAIR OF NUMBERS WHICH RATE: (1) THE PROBABILITYTHAT THE SUBSTANCE IS A CARCINOGEN, AND (2) THE RELIABILITY OF THE TEST RESULTS ON WHICH THAT PROBABILITY IS BASED. THESE TWO RATINGS WILL BE COMBINED INTO A CARCINOGENICITY RATIO WHICH WILL BE APPLIED TO EACH FACTOR. IN ADDITION, EACH PHYSICAL-CHEMICAL DATAPOINT WILL BE CODED WITH A QUALITY INDICATOR WHERE POSSIBLE. RESULTS OF THE PHASE I EFFORT WILL PROVIDE THE BASIS FOR COMPILING AND IMPLEMENTINGAN EVALUATED DATABASE FOR OVER 1000 KNOWN AND POTENTIAL CARCINOGENS DURING PHASE II. THE DATABASE AND ITS ASSOCIA- TED SOFTWARE WILL BE SUITABLE FOR ONLINE SEARCH AND RETRIEVAL AND AS MACHINE-READABLE PRODUCTS FOR RESEARCHERS INTO ONCOLOGIC EFFECTS.

* information listed above is at the time of submission.

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