AN IN VITRO TOXICITY TESTING DATABANK

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$46,269.00
Award Year:
1990
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
13764
Agency Tracking Number:
13764
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
10 Columbus Cir #2300, New York, NY, 10019
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Mildred R Green
(212) 245-0044
Business Contact:
() -
Research Institute:
n/a
Abstract
ADVANCES IN BIOTECHNOLOGY HAVE LED TO THE DEVELOPMENT OF NEWIN VITRO TOXICITY TESTING METHODOLOGIES THAT ARE APPLICABLE TO THE EVALUATION OF CHEMICAL SAFETY. IMPETUS FOR THE DEVELOPMENT OF IN VITRO TESTS DERIVES FROM THE NEED FOR RAPID, INEXPENSIVE, AND MORE HUMANE APPROACHES THAT MAY SERVE AS ALTERNATIVES TO TESTS INVOLVING WHOLE ANIMALS. HOWEVER, THE IMPLEMENTATION OF IN VITRO METHODOLOGIES HAS BEEN SLOWED BECAUSE VALIDATION FOR SPECIFIC APPLICATIONS HASNOT BEEN ESTABLISHED. THIS RESEARCH AIMS TO DEVELOP THE IN VITRO TOXICITY TESTING DATABANK (IVT), WHICH WILL INTEGRATE AN INVENTORY OF TEST PROCEDURES AND EXPERIMENTAL DATA FOR VALIDATION PURPOSES. THE OBJECTIVES ARE TO: (1) COMPILE A COMPLETE INVENTORY OF IN VITRO METHODOLOGIES, (2) MAINTAIN AND UPDATE AN EXPERIMENTAL DATA COLLECTION REQUIRED FOR VALIDATING NEW TESTS, (3) DEVELOP AN AUTOMATED INSTRUMENT FOR COMMUNICATINGWITH SCIENTISTS WHO ARE DEVELOPING AND APPLYING NEW METHODOLOGIES, AND (4) MAINTAIN A COMPUTERIZED SYSTEM THROUGH WHICH INDUSTRY, GOVERNMENT AGENCIES, AND ACADEMIA CAN ACCESS INFORMATION REQUIRED FOR THE VALIDATION AND SELECTION OF AVAILABLE TESTS. IN PHASE I, A PROTOTYPE DATABASE OF IN VITRO TESTS FOR CYTOTOXICITY AND OCULAR IRRITATION WILL BE DEVELOPED. IN PHASE II, THE DATABANK WILL BE EXPANDED TO INCLUDE NEW TEST CATEGORIES AND SOFTWARE THAT WILL MAKE IVT SUITABLE FOR ONLINE ACCESS.

* information listed above is at the time of submission.

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