MAGNETIC RESONANCE IMAGING OF PERFUSION OF BLOOD IN ORGANS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
8074
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Technical Research Assocs Inc
410 Chipeta Way Ste 222, Salt Lake City, UT, 84108
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
TRA PROPOSES TO APPLY NUCLEAR MAGNETIC RESONANCE IMAGING (MRI) TECHNIQUES TO INVESTIGATE PERFUSION OF BLOOD IN THE ORGANS. THE AIM OF THIS PROJECT IS TO DEVELOP A MODEL OF PERFUSION AND TO ESTABLISH PROCEDURES AND FORMALISMS FOR OBTAINING INFORMATION ABOUT THE SPECIFIC PERMEABILITY AND VOID FRACTION OF THE VASCULAR BED, PERMEABILITY OF THE CAPILLARY ENDOTHELIUM, KINETIC COEFFICIENTS AND EXTRACTION RATIO, IN ADDITION TO DISPERSION AND MEAN BULK VELOCITY. TRA PROPOSES A STATISTICAL HYDRODYNAMIC MODEL WITH A HYDRODYNAMIC DISPERSION COEFFICIENT AND DARCY'S VELOCITY. THIS DISPERSION, ALTHOUGH SUPERFICIALLY SIMILAR TO BROWNIAN OR TURBULENT DIFFUSION, IS PHYSICALLY DIFFERENT. PHASE I WORK WILL INVESTIGATE ONLY THE VASCULAR BED, AND THE MAIN FOCUS WILL BE ON SIMULATIONAL AND NUMERICAL WORK. INVESTIGATION OF THE TISSUE CHAMBER AND EXCHANGE KINETICS WILL BE UNDERTAKEN IN PHASE II IN WHICH PHASE STYLIZED PHANTOM EXPERIMENTS WILL ALSO BE PERFORMED.

* information listed above is at the time of submission.

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