ULTRASOUND-ENHANCED INVERTED BONE MARROW FRACTIONATION

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
13968
Agency Tracking Number:
13968
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
410 Chipeta Way #222, Salt Lake City, UT, 84108
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Owen D Brimhall
(801) 582-8080
Business Contact:
() -
Research Institute:
n/a
Abstract
THE OVERALL OBJECTIVE OF THIS PROJECT IS TO DESIGN, DEVELOP, AND CONSTRUCT A BONE MARROW SEPARATION DEVICE THAT WILL OFFER SIGNIFICANTLY SUPERIOR PERFORMANCE COMPARED WITH CURRENT METHODS OF VELOCITY SEDIMENTATION. IN PHASE I, TECHNICAL RESEARCH ASSOCIATES, INC. (TRA) WILL APPLY PATENTED PSEUDOSTANDING WAVE ULTRASOUND TECHNOLOGIES TO SEPARATE BONE MARROW CELLS BY SIZE. THIS NOVEL DEVICE WILL ELIMINATE THE TRADITIONAL CELL CONCENTRATION PROBLEM REFERRED TO AS THE "STREAMING LIMIT" ASSOCIATED WITH VELOCITY SEDIMENTATION, USING AN ACOUSTICALLY INVERTED SEPARATION COLUMN. USING SAFE LEVELS OF ULTRASOUND, THE FORCES GENERATED BY TRA'S ULTRASONIC MEANS ARE SIGNIFICANTLY HIGHER THAN TRADITIONAL "G" FORCES AND WILL EFFECT RAPID CELL SEPARATION. THE USE OF ULTRASONICALLY GENERATED VELOCITY GRADIENTS WILL ALSO ELIMINATE THE NEED FOR THE TEDIOUS AND DIFFICULT FORMATION OF DENSITY GRADIENTS ASSOCIATED WITH STANDARD VELOCITY SEDIMENTATIONS. THIS TECHNIQUE, WHEN INTEGRATED INTO COMMERCIAL SEPARATION SYSTEMS, WILL PROVIDE MORE EFFICIENT COLLECTION OF SPECIFIC BONE MARROW AND OTHER BIOLOGICAL CELLS FOR CLINICAL TREATMENT. THE DEVICE WILL ALSO SAVE TIME, DECREASE COSTS, AND PROVIDE UNIQUE PERFORMANCE FOR THOSE INTERESTED IN FRACTIONATION OF BULK QUANTITIES OF CELLS OR BONE MARROW COMPONENTS.

* information listed above is at the time of submission.

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