ULTRASOUND-ENHANCED INVERTED BONE MARROW FRACTIONATION

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 13968
Amount: $500,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1992
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
410 Chipeta Way #222, Salt Lake City, UT, 84108
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Owen D Brimhall
 (801) 582-8080
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE OVERALL OBJECTIVE OF THIS PROJECT IS TO DESIGN, DEVELOP, AND CONSTRUCT A BONE MARROW SEPARATION DEVICE THAT WILL OFFER SIGNIFICANTLY SUPERIOR PERFORMANCE COMPARED WITH CURRENT METHODS OF VELOCITY SEDIMENTATION. IN PHASE I, TECHNICAL RESEARCH ASSOCIATES, INC. (TRA) WILL APPLY PATENTED PSEUDOSTANDING WAVE ULTRASOUND TECHNOLOGIES TO SEPARATE BONE MARROW CELLS BY SIZE. THIS NOVEL DEVICE WILL ELIMINATE THE TRADITIONAL CELL CONCENTRATION PROBLEM REFERRED TO AS THE "STREAMING LIMIT" ASSOCIATED WITH VELOCITY SEDIMENTATION, USING AN ACOUSTICALLY INVERTED SEPARATION COLUMN. USING SAFE LEVELS OF ULTRASOUND, THE FORCES GENERATED BY TRA'S ULTRASONIC MEANS ARE SIGNIFICANTLY HIGHER THAN TRADITIONAL "G" FORCES AND WILL EFFECT RAPID CELL SEPARATION. THE USE OF ULTRASONICALLY GENERATED VELOCITY GRADIENTS WILL ALSO ELIMINATE THE NEED FOR THE TEDIOUS AND DIFFICULT FORMATION OF DENSITY GRADIENTS ASSOCIATED WITH STANDARD VELOCITY SEDIMENTATIONS. THIS TECHNIQUE, WHEN INTEGRATED INTO COMMERCIAL SEPARATION SYSTEMS, WILL PROVIDE MORE EFFICIENT COLLECTION OF SPECIFIC BONE MARROW AND OTHER BIOLOGICAL CELLS FOR CLINICAL TREATMENT. THE DEVICE WILL ALSO SAVE TIME, DECREASE COSTS, AND PROVIDE UNIQUE PERFORMANCE FOR THOSE INTERESTED IN FRACTIONATION OF BULK QUANTITIES OF CELLS OR BONE MARROW COMPONENTS.

* Information listed above is at the time of submission. *

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