Polycrystalline LuAlO3:Ce Scintillators for PET Applications

Award Information
Agency: Department of Energy
Branch: N/A
Contract: DE-FG02-06ER84438
Agency Tracking Number: 80499S06-I
Amount: $99,935.00
Phase: Phase I
Program: SBIR
Awards Year: 2006
Solicitation Year: 2005
Solicitation Topic Code: 10
Solicitation Number: DE-FG01-05ER05-28
Small Business Information
Technology Assessment and Transfer, Inc.
133 Defense Highway, Suite 212, Millersville, MD, 21401
DUNS: N/A
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Eric Gulliver
 Dr.
 (410) 987-8988
 egulliver@techassess.com
Business Contact
 Sharon Fehrenbacher
Title: Dr.
Phone: (410) 224-3710
Email: sharon@techassess.com
Research Institution
N/A
Abstract
Although PET imaging, a technology used in medicine, has advanced rapidly in recent decades, further advances will depend on improvements in the scintillator materials. New materials have been identified, but they are unstable under the conditions used for single crystal growth, leading frequently to poor quality. LuAlO3:Ce appears to be an excellent candidate for PET applications, but the challenges associated with growing single crystals of this material make the task of commercialization and optimization especially challenging. This project will utilize powder synthesis and ceramic processing to develop transparent polycrystalline scintillators from LuAlO3:Ce. In Phase I, sol-gel synthesis will be used to produce comositionally homogeneous powders of LuAlO3:Ce. These powders will be formed into green bodies and sintered to transparency. The properties of these scintillators will be evaluated and compared against the single crystal materials currently used for PET. The scintillation characterisics of the powders will be evaluated as a fast screening tool for material optimization, through adjustments of dopant and co-dopant additions. Commercial Applications and Other Benefits as described by the Applicant: Transparent ceramic scintillators would be expected to benefit the health care and pharmaceutical industries, enhancing the spatial resolution of PET imaging. Ceramic scintillators would be less expensive and easier to produce than single crystals of the same materials. Ultimately, these advances would have a beneficial impact on the early identification of diseases such as cancer, which is less costly to treat when diagnosed early. In addition, the pharmaceutical industry may benefit by shortening clinical and pre-clinical trials, through better correlation between small animal and human studies

* information listed above is at the time of submission.

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