Transcutaneous Noninvasive Device for the Responsive Delivery of Melatonin in Microgravity.

Award Information
Agency:
National Aeronautics and Space Administration
Amount:
$70,000.00
Program:
SBIR
Contract:
NNJ06JD50C
Solitcitation Year:
2005
Solicitation Number:
N/A
Branch:
N/A
Award Year:
2006
Phase:
Phase I
Agency Tracking Number:
055376
Solicitation Topic Code:
X11.02
Small Business Information
Technova Corporation
1232 Mizzen Drive, Okemos, MI, 48864-3480
Hubzone Owned:
N
Woman Owned:
Y
Socially and Economically Disadvantaged:
N
Duns:
015442887
Principal Investigator
 Serban Peteu
 Principal Investigator
 (517) 485-1402
 serbanpeteu@aol.com
Business Contact
 Serban Peteu
Title: Research Manager
Phone: (517) 485-1402
Email: serbanpeteu@aol.com
Research Institution
N/A
Abstract
Our goal is develop a smart, transcutaneous device for individualized circadian (sleep) therapy by responsive release of melatonin, in microgravity. Additionally, this concept ?shown in figure 1?is modular and multifunctional by design. So, with minimal changes, we envision being able to use same device for the controlled release of other medicines and nutrients, in space as well as on Earth. For space-travel, a variety of countermeasures must be developed to oppose the harmful effects of longterm flights and exposures to other gravitational fields. Furthermore, each astronaut responds to a certain medicine or combination of medicines in a unique manner. Circadian disruption, or acute (chronic) degradation of sleep quality or quantity, is a known risk during space-flight. Techova will develop a unique device for the responsive delivery of melatonin, integrating (i) inherently conductive polymer-based valves, (ii) nano- and micro-structured sensors and (iii) non-invasive virtually pain-free micro-needle arrays. Our team builds upon previous research critically needed to develop this novel transdermal release device. The ability to monitor the progression of circadian (sleep) disruption and respond to the unique changes in the body chemistry of each individual (patient) offers an unprecedented opportunity to deliver specific, personalized medical care during space flight.

* information listed above is at the time of submission.

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