SPECIALIZED MEMBRANES FOR CONCENTRATION OF GASTRIC PEPTIDES

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 7247
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
200 Homer Avenue, Ashland, MA, 01721
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MITCHELL KLAUSNER
 (617) 881-6771
Business Contact
Phone: () -
Research Institution
N/A
Abstract
CURRENT SYSTEMS FOR CONCENTRATION OF GASTRIC PEPTIDES FROM RATS AND DOGS RELY ON REGENERATED CELLULOSE MEMBRANES THAT ARE IMPLANTED INTO THE STOMACH WALL. THESE MEMBRANES BLOCK ADSORPTION OF THE PEPTIDES THEY ARE DESIGNED TO CARRY; ONLY 5 TO 30 PERCENT OF THE BULK CONCENTRATION IS OBSERVED. THIS RESEARCH PROGRAM WILL DEVELOP A NEW MEMBRANE THAT DEMONSTRATES ENHANCED PERMEATION TO CHARGED PEPTIDES, SUCH AS GASTRIN-RELEASING PEPTIDE, GRP-10, PERMITTING HIGHER PERMEATION AND LONGER LIFETIME OF THE MEMBRANE IN THE STOMACH ENVIRONMENT. THIS WILL BE ACCOMPLISHED BY THE DEVELOPMENT OF A SUITABLE MEMBRANE SUBSTRATE, SUCH AS POLYSULFONE, DESIGNED TO SPECIFIED SIZE TO ENHANCE PERMEATION OF THE BULKY PROTEINS. IN ADDITION, LOW-TEMPERATURE PLASMA TREATMENT OF THE MEMBRANE WILL IMPARTDESIRABLE CHEMICAL FUNCTIONALITY TO ENHANCE PERMEATION OF HIGHLY POLAR SPECIES.

* Information listed above is at the time of submission. *

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