MOLECULAR MIMICRY AFFINITY CHROMATOGRAPHY

Award Information
Agency:
Department of Energy
Branch
n/a
Amount:
$50,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7712
Agency Tracking Number:
7712
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
165 Eighth Street #306, San Francisco, CA, 94103
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
LAWRENCE M KAUVAR
() -
Business Contact:
Jerrold L Glick
(303) 623-1221
Research Institute:
n/a
Abstract
SUPERIOR SEPARATION COLUMNS ARE BEING DEVELOPED IN THIS PROJECT TO BE USED WITH HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) SYSTEMS TO DETECT ENVIRONMENTAL TOXINSSUCH AS DDT. THE SEPARATION AND ANALYSIS OF COMPOUNDS BY HPLC SYSTEMS DEPENDS ON THE AMPLIFICATION OF SMALL DIFFERENCES IN THE RELATIVE AFFINITY OF THE COMPOUNDS BETWEEN THE COLUMN MATRIX AND THE SOLVENT. USING A FEW STANDARDIZED COLUMN MATRICES, CURRENT HPLC PROCEDURES REQUIRE ADJUSTMENT OF SOLVENT COMPOSITION TO PROVIDE ADEQUATE SEPARATION OF THE COMPOUNDS. BY CONTRAST, THE CURRENT WORK WILL OPTIMIZE THE COLUMN FOR PREFERENTIAL BINDING OF THE TARGET ANALYTE BY ATTACHING SELECTED MEMBERS OF A NOVEL CLASS OF AFFINITY LIGANDS TO THE COLUMN MATRIX.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government