MOLECULAR MIMICRY AFFINITY CHROMATOGRAPHY

Award Information
Agency: Department of Energy
Branch: N/A
Contract: N/A
Agency Tracking Number: 7712
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1988
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
Terrapin Diagnostics Ltd
165 Eighth Street #306, San Francisco, CA, 94103
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 LAWRENCE M KAUVAR
 () -
Business Contact
 Jerrold L Glick
Phone: (303) 623-1221
Research Institution
N/A
Abstract
SUPERIOR SEPARATION COLUMNS ARE BEING DEVELOPED IN THIS PROJECT TO BE USED WITH HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) SYSTEMS TO DETECT ENVIRONMENTAL TOXINSSUCH AS DDT. THE SEPARATION AND ANALYSIS OF COMPOUNDS BY HPLC SYSTEMS DEPENDS ON THE AMPLIFICATION OF SMALL DIFFERENCES IN THE RELATIVE AFFINITY OF THE COMPOUNDS BETWEEN THE COLUMN MATRIX AND THE SOLVENT. USING A FEW STANDARDIZED COLUMN MATRICES, CURRENT HPLC PROCEDURES REQUIRE ADJUSTMENT OF SOLVENT COMPOSITION TO PROVIDE ADEQUATE SEPARATION OF THE COMPOUNDS. BY CONTRAST, THE CURRENT WORK WILL OPTIMIZE THE COLUMN FOR PREFERENTIAL BINDING OF THE TARGET ANALYTE BY ATTACHING SELECTED MEMBERS OF A NOVEL CLASS OF AFFINITY LIGANDS TO THE COLUMN MATRIX.

* information listed above is at the time of submission.

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