SHORT PEPTIDES FOR AFFINITY CHROMATOGRAPHIC SEPARATIONS OF PROTEINS

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: N/A
Agency Tracking Number: 11871
Amount: $250,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1991
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Terrapin Diagnostics Inc.
165 Eighth Street #306, San Francisco, CA, 94103
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Dr Lawrence M Kauvar
 V P & Director R & D
 () -
Business Contact
Phone: (415) 431-5499
Research Institution
N/A
Abstract
TERRAPIN DIAGNOSTICS, INC. HAS APPLIED ITS PROPRIETARY TECHNOLOGY IN THE AREA OF MOLECULAR MIMICRY TO THE DEVELOPMENT OF LIQUID CHROMATOGRAPHY "PARALOG" (PARATOPE ANALOG) LIGANDS, WHICH CAN BE USED FOR PROTEIN PURIFICATION AND ANALYSIS. INITIAL EMPIRICAL RESULTS INDICATE THAT THESELIGANDS HAVE NOVEL PROPERTIES COMPARED TO EXISTING CHROMATOGRAPHIC MEDIA, AS EXPECTED THEORETICALLY, AND SHOULDTHEREFORE BE USEFUL IN SEPARATING PROTEINS FROM EACH OTHER BY CRITERIA DISTINCT FROM THOSE CURRENTLY AVAILABLE. ACCORDINGLY, IT IS ANTICIPATED THAT TERRAPIN'S LIGANDS WILL BE USEFUL IN THE INITIAL PURIFICATION OF NOVEL PROTEINS, IN THE PREPARATIVE SCALE MANUFACTURE OF KNOWN PROTEINS, AND IN THE PURITY ANALYSIS OF RECOMBINANT PROTEINS INTENDED FOR THERAPEUTIC APPLICATIONS. THE PROPOSED RESEARCH COVERS EXAMINATION OF THE DEGREE OF DIVERSITY OF THE NOVEL LIGANDS AMONGST THEMSELVES, AS WELL AS EXPLORATION OF THEIR OPERATING CHARACTERISTICS WHEN COUPLED TO A SUITABLE CHROMATOGRAPHIC SORBENT.

* information listed above is at the time of submission.

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