SHORT PEPTIDES FOR AFFINITY CHROMATOGRAPHIC SEPARATIONS OF PROTEINS

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$250,000.00
Award Year:
1991
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
11871
Agency Tracking Number:
11871
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
165 Eighth Street #306, San Francisco, CA, 94103
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr Lawrence M Kauvar
V P & Director R & D
() -
Business Contact:
(415) 431-5499
Research Institute:
n/a
Abstract
TERRAPIN DIAGNOSTICS, INC. HAS APPLIED ITS PROPRIETARY TECHNOLOGY IN THE AREA OF MOLECULAR MIMICRY TO THE DEVELOPMENT OF LIQUID CHROMATOGRAPHY "PARALOG" (PARATOPE ANALOG) LIGANDS, WHICH CAN BE USED FOR PROTEIN PURIFICATION AND ANALYSIS. INITIAL EMPIRICAL RESULTS INDICATE THAT THESELIGANDS HAVE NOVEL PROPERTIES COMPARED TO EXISTING CHROMATOGRAPHIC MEDIA, AS EXPECTED THEORETICALLY, AND SHOULDTHEREFORE BE USEFUL IN SEPARATING PROTEINS FROM EACH OTHER BY CRITERIA DISTINCT FROM THOSE CURRENTLY AVAILABLE. ACCORDINGLY, IT IS ANTICIPATED THAT TERRAPIN'S LIGANDS WILL BE USEFUL IN THE INITIAL PURIFICATION OF NOVEL PROTEINS, IN THE PREPARATIVE SCALE MANUFACTURE OF KNOWN PROTEINS, AND IN THE PURITY ANALYSIS OF RECOMBINANT PROTEINS INTENDED FOR THERAPEUTIC APPLICATIONS. THE PROPOSED RESEARCH COVERS EXAMINATION OF THE DEGREE OF DIVERSITY OF THE NOVEL LIGANDS AMONGST THEMSELVES, AS WELL AS EXPLORATION OF THEIR OPERATING CHARACTERISTICS WHEN COUPLED TO A SUITABLE CHROMATOGRAPHIC SORBENT.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government