Prodrugs

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$70,000.00
Award Year:
2008
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-09-C-0007
Award Id:
87277
Agency Tracking Number:
A082-123-0545
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
9063 Bee Caves Road, Austin, TX, 78733
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
625120902
Principal Investigator:
ChrisPavlos
Principal Investigator
(512) 263-2101
cpavlos@tri-austin.com
Business Contact:
MonteFellingham
Contracts Administrator
(512) 263-2101
mfellingham@tri-austin.com
Research Institute:
n/a
Abstract
Cancer, the second leading cause of death in the United States, is diagnosed in more than one million people per year. Radiation and chemotherapy are systemically toxic treatments that indiscriminately kill healthy cells and cancer cells alike. Chemotherapy could be significantly improved by selectively targeting cancer cells. Prodrugs, chemotherapeutic precursors that become active either over time or at a target site, are of interest here. Most prodrugs benefit from either increased temporal control (timed release), or increased spatial control (targeted release). However, very few prodrugs have both temporal and spatial control. TRI/Austin is proposing to develop a prodrug based on a conjugate of poly(ethylene glycol) (PEG) and Floxuridine that can be activated by UV light. The PEG renders the prodrug completely non-toxic. Due to the enhanced permeation and retention (EPR) effect of PEG conjugates in solid tumors, the prodrug will selectively accumulate in cancer tissue. Once activated by UV light, Floxuridine is released and signals apoptosis. The PEG byproduct, as well as any un-activated prodrug, is eventually cleared from the body. This approach minimizes the systemic toxicity of common chemotherapeutics, and can be applied to most existing cancer drugs.

* information listed above is at the time of submission.

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