DEVELOPMENT OF A HIGHLY COMPLIANT VASCULAR GRAFT

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$263,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
3257
Agency Tracking Number:
3257
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2023 Eighth St., Berkeley, CA, 94710
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Philip Litwak
Principal Investigator
(415) 841-1213
Business Contact:
() -
Research Institute:
n/a
Abstract
A NEW, HIGHLY COMPLIANT VASCULAR GRAFT FABRICATED FROM A UNIQUE POLYURETHANE MATERIAL WILL BE DEVELOPED AND TESTED. THE BULK AND SURFACE PROPERTIES REQUIRED OF THIS MATERIAL HAVE BEEN DECOUPLED AND DEVELOPED INDEPENDENTLY IN TWO SEPARATE MATERIALS. THE FINAL POLYMER WILL POSSESS OVERALL OPTIMIZED CHARACTERISTICS BY BLENDING OPTIMIZED SURFACE ACTIVE COPOLYMERS INTO THE OPTIMIZED BULK MATERIAL. USING A PATENTED PROCESS FOR FABRICATION OF MULTILAYERED TUBING, 4 MM DIAMETER VASCULAR GRAFTS WILL BE PRODUCED. THESE GRAFTS WILL BE TESTED BOTH IN VIVO AND IN VITRO. IN VITRO TESTING WILL INCLUDE COMPLIANCE, BURST STRENGTH, KINK RADIUS, ELONGATION, AND SUTURE PULLOUT STRENGTH. IN VIVO EVALUATION WILL BE ACCOMPLISHED BY IMPLANTING 8 CM LENGTHS IN THE CAROTID ARTERIES OF MATURE GOATS. THESE WILL BE CHECKED FOR PATENCY EVERY 30 DAYS USING 99MTECHNETIUM SCANNING. AFTER 60 DAYS OF OBSERVATION, GRAFTS WILL BE EXPLANTED AND RESUBJECTED TO THE IN VITRO TEST PROTOCOL. ADDITIONALLY, BOTH SEM AND STANDARD MICROSCOPIC EXAMINATIONS WILL BE PERFORMED.

* information listed above is at the time of submission.

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