WE INTEND TO INVESTIGATE THE POTENTIAL FOR LIPOSOME ENCAPSULATION OF LYMPHOTOXIN AND ITS DELIVERY TO SPECIFIC LIVER CELLS WHERE LYMPHOTOXIN CAN AUGMENT A NATURAL RESPONSE AGAINST TUMOR.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,645.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
3105
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Therapeutic Delivery Systems
3 Manlon Terrace, Buffalo, NY, 14225
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
JAMES R. WILSON
PRINCIPAL INVESTIGATOR
(716) 845-2025
Business Contact:
() -
Research Institution:
n/a
Abstract
WE INTEND TO INVESTIGATE THE POTENTIAL FOR LIPOSOME ENCAPSULATION OF LYMPHOTOXIN AND ITS DELIVERY TO SPECIFIC LIVER CELLS WHERE LYMPHOTOXIN CAN AUGMENT A NATURAL RESPONSE AGAINST TUMOR. UNDERSTANDING HOW THE HOST'S NATURAL DEFENSE SYSTEM CAN BE MODULATED BY CHEMOTHERAPEUTIC DRUGS AND BRMS IN A NUMBER OF PATHOLOGIC STATES IS CRITICAL IN DETERMINING THEIR CLINICAL USEFULNESS. SINCE THE LIVER IS A MAJOR TARGET OF INVASION BY METASTATIC TUMORS, WE HAVE SELECTED IT AS A MODEL ORGAN TO ACCOMPLISH OUR RESEARCH AIMS. WE HAVE DEVELOPED, AND WILL EMPLOY IN THIS PROJECT, TECHNIQUES TO STUDY THE LIVER'S NATURAL ANTITUMOR DEFENSE SYSTEM IN VITRO/EX VITRO AS WELL AS METHODS TO TARGET IMMUNOENHANCING AGENTS TO VARIOUS REGIONS OF THE MURINE LIVER USING LIPOSOMES OF VARIED SIZE AND COMPOSITION.

* information listed above is at the time of submission.

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