THE LONG-TERM OBJECTIVE OF THE PROPOSED PROJECT IS THE DEVELOPMENT OF A MOUTHRINSE SYSTEM CAPABLE OF MAINTAINING THERAPEUTIC LEVELS OF FLUORIDE AT THE TOOTH SURFACE FOR A DURATION OF UP TO 8 HOURS.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4863
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Theratech Inc
417 Wakara Way, Room 290, Salt Lake City, UT, 84108
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 DINESH C PATEL
 PRINCIPAL INVESTIGATOR
 (801) 583-6028
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE LONG-TERM OBJECTIVE OF THE PROPOSED PROJECT IS THE DEVELOPMENT OF A MOUTHRINSE SYSTEM CAPABLE OF MAINTAINING THERAPEUTIC LEVELS OF FLUORIDE AT THE TOOTH SURFACE FOR A DURATION OF UP TO 8 HOURS. CURRENTLY AVAILABLE SELF-APPLIEDFLUORIDE DELIVERY SYSTEMS (MOUTHRINSES AND TOOTHPASTES) MAINTAIN FLUORIDE LEVELS FOR ONLY A FEW MINUTES AT BEST, WHEREAS THE MORE ROBUST PROFESSIONALLY APPLIED TREATMENTS SUCH AS GELS ARE APPLIED AT THE MOST ONCE EVERY FEW MONTHS. PREVIOUS CONCEPT DEMONSTRATION STUDIES HAVE SHOWN THAT THE ACHIEVEMENT OF THIS OBJECTIVE WOULD RESULT IN SYSTEMS CAPABLE OF ALMOST COMPLETELY REMINERALIZING DEVELOPING CARIOUS LESIONS ON A DAILY BASIS. THE SYSTEM TO BE DEVELOPED WILL USE MICRONIZED CALCIUM FLUORIDE PARTICLES AS A PROLONGED RELEASE FLUORIDE SOURCE. THESE PARTICLES WILL BE SUSPENDED IN A POLYMER SOLUTION MOUTHRINSE SYSTEM DESIGNED TO MAXIMIZE THE ADHERENCE OF THE PARTICLES TO THE TOOTH PELLICLE. THE GOAL OF THIS PHASE I PROJECT IS TO FINDTHE OPTIMAL SYSTEM OF THOSE TESTED AS MEASURED BY THE IN VITRO ABILITY TO MAINTAIN THERAPEUTIC FLUORIDE LEVELS AT TOOTH SURFACES. PHASE II WILL BE CONCERNED WITH A MORE DETAILED DEMONSTRATION OF THE EFFECTIVENESS OF THE CHOSEN SYSTEM USING BOTH IN VITRO AND HUMAN IN VIVO MODELS AS WELL AS THE FURTHER REFINEMENT NECESSARY TO ACHIEVE A PRACTICAL COMMERCIAL SYSTEM.

* information listed above is at the time of submission.

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