SCANNED, FOCUSED ULTRASOUND HYPERTHERMIA SYSTEM

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7177
Agency Tracking Number:
7177
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
One Cambridge Center, Cambridge, MA, 02142
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
HOWARD L RESNIKOFF PHD
(617) 225-2464
Business Contact:
() -
Research Institute:
n/a
Abstract
HYPERTHERMIA, ALONE OR IN COMBINATION WITH CHEMOTHERAPY AND/OR RADIATION, IS RAPIDLY EMERGING AS AN EFFECTIVE MODALITY FOR CANCER THERAPY. IT IS GENERALLY AGREED THAT AMONG THE CURRENTLY AVAILABLE TECHNIQUES, SCANNED, INTENSITY-MODULATED ULTRASOUND (SIMFU) HAS THE BEST POTENTIAL FOR LOCALIZED HEATING OF DEEP TUMORS IN MOST ANATOMICAL LOCATIONS. BASED ON CLINICAL RESULTS OBTAINED FROM APPROXIMATELY 200 CANCER PATIENTS AT THE HARVARD-MIT HYPERTHERMIA CENTER WITH THE PROTOTYPE SIMFU RESEARCH SYSTEM, THERE IS CONSIDERABLE DEMAND FOR A CLINICAL SIMFU SYSTEM WITH COMPARABLE PERFORMANCE. USING THE WELL-DOCUMENTED SIMFU SYSTEM AS THE BASIC MODEL, THE MAJOR GOAL OF THIS PHASE I PROJECT IS TO INVESTIGATE THEFEASIBILITY OF DESIGNING A COMMERCIALLY VIABLE, SCANNED, FOCUSED ULTRASOUND HYPERTHERMIA SYSTEM THAT IS COST EFFECTIVE, CAN BE ROUTINELY ADMINISTERED IN THE CLINICAL SETTING, IS CAPABLE OF TREATING A WIDE VARIETY OF TUMORS, AND IS RELIABLE AND UPGRADABLE. THE EXISTING SIMFU HYPERTHERMIA SYSTEM CURRENTLY IS USE AT THE HYPERTHERMIA CENTER HAS EVOLVED DEVELOPMENTALLY OVER THE LAST 10 YEARS INA RESEARCH ENVIRONMENT. CONSEQUENTLY, IT IS COMPLEX, COSTLY, AND DIFFICULT TO OPERATE. PHASE I FUNDING IS REQUIRED TO DEVELOP THE SPECIFICATIONS NECESSARY FOR STANDARDIZED CLINICAL USE.

* information listed above is at the time of submission.

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