DECELERATION VELOCITY COMPACTION TOF MASS SPECTROMETER

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$472,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
3364
Agency Tracking Number:
3364
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P.o. Box 12877, Gainesville, FL, 32604
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Luis Muga
Principal Investigator
(904) 472-2668
Business Contact:
() -
Research Institute:
n/a
Abstract
BASIC AND CLINICAL RESEARCH IN THE BIOMEDICAL SCIENCES DEMANDS IMPROVED INSTRUMENTATION FOR ACCURATE MEASUREMENT AND RELIABLE ANALYSIS. THE OBJECTIVE OF THIS RESEARCH IS TO IMPROVE THE MASS RESOLUTION OF THE TIME-OF-FLIGHT MASS SPECTROMETER (TOF MS) SUCH THAT IT WILL BE COMPETITIVE WITH CURRENTLY SUPERIOR, BUT MORE EXPENSIVE, HIGH-RESOLUTION MASS SPECTROMETERS. IN THE PROPOSED RESEARCH THE BASIC RELATIONS FOR A NEW ION FOCUSING PRINCIPLE, TERMED VELOCITY COMPACTION (VC), WILL BE DERIVED FOR A DECELERATION FIRST STAGE FOLLOWING A HIGH-VOLTAGE ION EXTRACTION SECTION AND IN TURN FOLLOWED BY AN ACCELERATION SECOND STAGE WITH AN EXPECTED RESOLUTION (M/MFWHM) IN EXCESS OF 10,000. A SERIES OF COMPUTER SIMULATIONS OF THE FLIGHT-TIMES WILL BE MADE, TAKING INTO ACCOUNT THE EFFECTIVE ION PLASMA TEMPERATURE. THE RESULT WILL BE A SERIES OF SIMULATED MASS SPECTRA FROM WHICH MASS RESOLUTION VALUES CAN BE PREDICTED. SIGNIFICANT TRENDS INFLUENCING THE MASS RESOLUTION WILL BE PLOTTED AND ANALYZED, AND A COMBINATION OF PRACTICAL DIMENSIONS WILL BE CHOSEN FOR A PROTOTYPE MODEL. BASED ON THESE RESULTS, DESIGN OF A DEMONSTRATION MODEL, DUAL-STAGE VELOCITY COMPACTION TOF MS WILL BEGIN.

* information listed above is at the time of submission.

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