Spinel Armor-Clearly More Cost Effective

Award Information
Agency:
Department of Defense
Amount:
$729,998.00
Program:
SBIR
Contract:
DAAD13-01-C-0005
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
Army
Award Year:
2001
Phase:
Phase II
Agency Tracking Number:
A992-2856
Solicitation Topic Code:
N/A
Small Business Information
TPL, INC.
3921 Academy Parkway North, NE, Albuquerque, NM, 87109
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
055145320
Principal Investigator
 Timothy Tiernan
 Director, Instrumentation
 (505) 342-4488
 jeannie@mide.com
Business Contact
 H. Stoller
Title: President & CEO
Phone: (505) 342-4412
Email: jeannie@mide.com
Research Institution
N/A
Abstract
The proposed biosensor will combine the selectivity of immobilized oligonucleotideprobes and the rapid and efficient collection capability of porous silicon membraneswith the mass sensitivity (picogram) of ultrasonic microelectronic devices. TPL hasdemonstrated methods to form funtionalized porous membranes for selective bindingof target oligonucleotides. The proposed device array will open unique opportunitiesfor real-time detection of nucleic acids and associated protein regulation. It isa direct measurement approach that does not require labeled or amplified DNA, andhybridization reaction rates are accelerated by improved mass transport afforded bysolution flow through the sensor. TPL, in collaboration with the Molecular DiagnosticsCore Laboratory (MDCL), University of New Mexico, has already demonstrated fabricationand functionality of individual porous membranes. Phase II multi-site membrane will befuntionalized and interrogated using a sequential, laser-coupled untrasonic system. Theresult will be a multi-site DNA sensing platform with sufficient sensitivity to avoid DNAamplification. TPL's experience in acoustic sensor design, which lead to Porotec, a thinfilm porosity analyzer employing acoustic wave transmission, combined with MDCL'sexpertise in clinical diagnostics by DNA sequencing will support development of porousmicrosensors for isolation and detection of DNA/mRNA sequences.

* information listed above is at the time of submission.

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