Thin Film Sensor for Specific DNA Sequences

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$97,754.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 AI38090-01,
Award Id:
29116
Agency Tracking Number:
29116
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
999 Chicago Avenue, Naperville, IL, 60540
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
William Penrose
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
A chemical sensor has been discovered which can be made to sensitively detect enzyme activity and aantibody reactions. It consists of an ultrathin (25 Angstroms) layer of platinum on an insulating sumeasure dielectric constant and other properties within molecular-scale distances of the surface. Wesensor be adapted to measure nucleic acid hybridization. Short, 20-nucleotide probes will be bound ttheir 3'-ends. Complementary strands will be hybridized with the probes, and the effect on the impedsensor will be observed. The double-stranded form will differ greatly in shape, electrostatic chargeall of which should affect the response of the thin-film sensor. Such a sensor may be useful as a rediagnostic tool for early HIV infection, genetic diseases, pathogen identification, and forensic pur

* information listed above is at the time of submission.

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