Integrated flow cytometer for on-line, real-time unlabeled bio detection in potable water

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$69,991.00
Award Year:
2005
Program:
SBIR
Phase:
Phase I
Contract:
W56HZV-06-C-0091
Award Id:
74135
Agency Tracking Number:
A052-243-0720
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
655 Phoenix Drive, Ann Arbor, MI, 48108
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
103627316
Principal Investigator:
Thomas Haddock
VP - Product Development
(734) 528-6135
tomhaddock@translume.com
Business Contact:
Eric Jacobson
VP - Finance
(734) 528-6371
ericjacobson@translume.com
Research Institute:
n/a
Abstract
Quantifying and classifying biological particles (bacteria, viruses, and cells) in drinking water and on beaches is critical to human health and environmental safety. The optimal solution is an on-line, real-time detection system continuously monitoring water without calibration or other attention. This technology has been elusive. Lab-on-a-chip ("LOC") PCR DNA detectors are viable contenders, but are a long way off. Flow cytometry uses optical techniques to detect and classify cells as they flow past in an on-line stream and integrates the cumulative signal to the desired detection level without pre-concentrators (another technology that is some time off). Translume's ability to write optical waveguides and complex microfluidic channels in a glass monolith enables a compact and robust micro flow cytometer (MFC), reducing this complex and delicate instrument into a simple single-piece unit. The MFC will address sample preparation, pre-concentration, and process time, all significant difficulties facing on-line water monitoring systems. Translume proposes to design and prototype an MFC in a single block of glass to determine the viability of this approach to yield a robust and field-deployable device for on-line water monitoring.

* information listed above is at the time of submission.

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