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Development of a Point-of-care Assay for the Detection of Crimean-Congo Haemorrhagic Fever (CCHF) Virus, a Militarily Important Pathogen of the CENTCO

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-09-C-0067
Agency Tracking Number: A083-181-0377
Amount: $70,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: A08-181
Solicitation Number: 2008.3
Solicitation Year: 2008
Award Year: 2009
Award Start Date (Proposal Award Date): 2009-01-27
Award End Date (Contract End Date): 2009-08-26
Small Business Information
145 North Sierra Madre Blvd., Suite #5
Pasadena, CA 91107
United States
DUNS: 011114167
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: Yes
Principal Investigator
 Hiep-Hoa Nguyen
 (714) 791-1774
Business Contact
 Sanjay Jayachandran
Title: Vice President
Phone: (626) 535-9496
Research Institution

The objective of this proposal is to develop point-of-care rapid test assay for the diagnosis of Crimean-Congo hemorrhagic fever. Selected surface membrane-bound glycoprotein antigens and the N-nucleoprotein from a number of Crimean-Congo hemorrhagic fever virus (CCHFV) strains will be prepared using powerful recombinant protein mass-production technologies. The purified recombinant antigens will be used to raise polyclonal and monoclonal antibodies quickly. The recombinant antigens and the corresponding antibodies will then be used for the preparation of nanoparticle conjugates. Subsequently, TransMembrane Biosciences’ partners, Pan Probe Biotech and Princeton BioMeditech will utilize these materials to construct point of care rapid test prototype(s) for the detection of CCHFV or IgM antibodies specific to CCHFV antigens in blood samples of patients.

* Information listed above is at the time of submission. *

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