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A Point-of-Care Assay for the Detection of Q fever

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-09-C-0041
Agency Tracking Number: A083-178-0375
Amount: $95,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: A08-178
Solicitation Number: 2008.3
Solicitation Year: 2008
Award Year: 2009
Award Start Date (Proposal Award Date): 2009-01-20
Award End Date (Contract End Date): 2010-01-15
Small Business Information
145 North Sierra Madre Blvd., Suite #5
Pasadena, CA 91107
United States
DUNS: 011114167
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: Yes
Principal Investigator
 Hiep-Hoa Nguyen
 (714) 791-1774
Business Contact
 Sanjay Jayachandran
Title: Vice President
Phone: (626) 535-9496
Research Institution

The objective of this proposal is to develop point-of-care rapid test assay for the diagnosis of Q-fever. Selected surface membrane protein antigens from Coxiella burnetii, the causative agent of Q-fever will be prepared using TransMembrane Biosciences’ powerful membrane protein mass production technologies. This methodology allows correctly folded and functional membrane proteins to be synthesized in large quantities. The purified recombinant antigens will be used to raise polyclonal and monoclonal antibodies quickly. The recombinant antigens and the corresponding antibodies will then be used for the preparation of nanoparticle conjugates. Subsequently, our industry partner, Pan Probe Biotech and Princeton BioMeditech will utilize these materials to construct point of care rapid test prototype(s) for the detection of C. burnetii or C. burnetii-specific IgM antibodies in blood samples of patients.

* Information listed above is at the time of submission. *

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