Transcutaneous electroacupuncture for gastroparesis

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
2009
Program:
SBIR
Phase:
Phase I
Contract:
1R43AT004489-01A2
Agency Tracking Number:
AT004489
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
TRANSTIMULATION RESEARCH, INC.
TRANSTIMULATION RESEARCH, INC., 921 NE 13TH ST (VRF/151), OKLAHOMA CITY, OK, 73104
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
602492642
Principal Investigator:
JIANDE CHEN
(832) 640-8111
JIANDECHEN@TRANSTIMULATION.COM
Business Contact:
JIANDE CHEN
() -
jiandechen@transtimulation.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Gastroparesis is a common disease defined as delayed emptying of the stomach. It is present in at least 20% of about 150 million patients with diabetes worldwide and in more than 20% of patients with functional dyspeps ia that affects about 10%-25% of the general population. Gastroparesis is a refractory disease with a lack of therapeutic options. Common symptoms of gastroparesis include nausea, vomiting, early satiety and abdominal bloating. Electroacupuncture (EA) is a combined procedure with acupuncture and electrical current stimulation instead of manual manipulations of the needles. Recent studies in our lab with EA or transcutaneous EA (TEA) have suggested a therapeutic role of EA or TEA for gastric motility disorde rs. Improvement has been observed with EA or TEA in gastric emptying as well as dyspeptic symptoms. In this project, a micro- stimulator is designed and developed for the TEA therapy. The micro-stimulator is small enough so that it can be attached to the s kin next to the stimulation electrodes and therefore the patient can resume normal daily activity while being treated by TEA. This is not only attractive but also more effective since TEA can be performed more often and for longer durations. This explorato ry project is designed to study the feasibility, efficacy and certain mechanisms of the proposed method of wireless TEA in patients with gastroparesis. Firstly the feasibility of the chronic use of the proposed micro-stimulator will be studied. Secondly, the efficacy of the TEA in improving delayed gastric emptying and symptoms of gastroparesis will be investigated in a double-blinded crossover design in patients with diabetic or idiopathic gastroparesis. Thirdly, possible mechanisms involving pathogenese s of gastroparesis with TEA will be investigated. A comprehensive team has been assembled to perform the study, including experts in gastrointestinal motility, traditional Chinese medicine and clinical patient care.

* information listed above is at the time of submission.

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