Oligonucleotides Inhibition of HIV-1 Integrase

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$65,956.00
Award Year:
1994
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 AI36115-1,
Award Id:
24785
Agency Tracking Number:
24785
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
9391 Grogans Mill Road, The Woodlands, TX, 77380
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Joshua Ojwang
(713) 363-8761
Business Contact:
() -
Research Institute:
n/a
Abstract
Effective therapy for human immunodeficiency virus (HIV) infection remains elusive, partly dueto the fact that infected long lived cells provide a reservoir for the virus. Currently availableanti-retroviral agents are reverse transcriptase inhibitors. In spite of their success, these compoundshave limited utility because their toxicity and lack of action have no effect on the production ofinfectious virus in cells harboring integrated provirus. Therefore, it is important to alternative approacheswhich target other factors important to the life cycle of the virus. This approach would involve targetingcompounds which interfere with the viral integrate enzyme in the HIV life cycle. Development ofclinically tolerable inhibitors of HIV integrate would have profound implications for anti- retroviral therapyby offering a wide range of application including potential synergy with the currently available reversetranscriptase inhibitors in acute HIV infections and as agents to target HIV-1 in chronically infected cells.We will design inhibitors targeted to HIV integrate and evaluate their therapeutic utility using in vitroassay systems. The promising compounds will further be evaluated in tissue culture and in vivo assaysystems.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government