Active Anti-HIV Guanosine/Thymidine Oligonucleotides

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 AI37332-01A1,
Award Id:
29101
Agency Tracking Number:
29101
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
9391 Grogans Mill Road, The Woodlands, TX, 77380
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Robert Rando
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
We will develop a new class of oligonucleotides, which fold themselves into ordered structures andmainly of deoxyguanosine and deoxythymidine (GTOs), as therapeutic antiviral agents active against HGTOs as antiviral agents represents the results of a productive investigation into the mechanism bymediate antiviral activity. Experiments described in the following preliminary results section demonguanosine/thymidine compound I100-15, with a phosphodiester (PD) backbone, is able to suppress HIV-1after removal of the drug from the viral infected cell culture is folded into an intramolecular strutranscription; may inhibit critical portions of HIV-1 replication and is not working by blocking virinteraction with the viral v3 loop. The experiments proposed in this Phase I grant application are svalidate the anti-human immunodeficiency virus type 1 (HIV-1) efficacy of 1100-15 by determining thestructure of this molecule and establishing the anti-HIV-1 mechanism of action. A secondary goal ofobtained structural information to rationally design modifications which will increase the anti-HIV-

* information listed above is at the time of submission.

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