Alkenylguanine Analogs--A New Class of Antiviral Agent

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 AI36788-01A1,
Agency Tracking Number: 29094
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1995
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Triplex Pharmaceutical
9391 Grogans Mill Road, The Woodlands, TX, 77380
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Arthur Lewis
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
We will develop certain structure activity relationships with respect to a novel class of antiviralconduct preliminary experiments designed to define the mechanism of action for these drugs. Preliminestablished that certain alkenes, when attached to a guanine congener, provide potential antiviral atherapeutic indices against debilitating, human, DNA viral infections . We will synthesize additionaactive compounds wherein certain structural variations will be made in the unsaturated hydrocarbon mcomparison of the antiviral activity of these additional derivatives will be used to construct a hypstructural features suggesting the most promising drug candidate. Information from simultaneous studof antiviral action of these drugs will be incorporated into the development of the model.

* information listed above is at the time of submission.

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