NONDESTRUCTIVE EVALUATION OF DRUGS AND BIOMATERIALS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
7298
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Tronac Inc
1804 South Columbia Lane, Orem, UT, 84058
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
PHILIP R. BROWN PHD
(801) 224-1131
Business Contact:
() -
Research Institution:
n/a
Abstract
THE OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A NONDESTRUCTIVE TECHNIQUE BASED ON MICROWATT BATCH CALORIMETRY TO STUDY THE DEGRADATION OF DRUGS (SOLID-STATE AND LIQUID FORMULATIONS), BIOCHEMICALS, AND BIOMATERIALS (E.G., THOSE USED IN ARTIFICIAL ORGANS). AS A RESEARCH TOOL, THE MICROWATT CALORIMETER IS COMPLEMENTARY TO, AND PROVIDES INFORMATION UNATTAINABLE BY, MORE SPECIFIC METHODS SUCH AS CHROMATOGRAPHY AND SPECTROPHOTOMETRY. THE AIM OF PHASE I IS TO ESTABLISH THE FEASIBILITY OF USING A MICROWATT CALORIMETER TO STUDY THE DEGRADATION OF SOLID-STATE DOSAGE FORMS OF DRUGS AND DRUG MIXTURES. THE EFFECT OF ALTERNATIVE HEAT SINK MATERIALS AND SAMPLE CHAMBERCONFIGURATIONS ON INSTRUMENT EQUILIBRATION, SENSITIVITY, AND ACCURACY WILL ALSO BE INVESTIGATED. IN PHASE II, AN INSTRUMENT WILL BE DESIGNED BASED ON PHASE I RESULTS. THE NEW INSTRUMENT WILL HAVE SOPHISTICATED ELECTRONIC CONTROL AND WILL BE USED TO STUDY A WIDE RANGE OF DRUGS, BIOCHEMICALS, AND BIOMATERIALS. THE SUCCESSFUL COMPLETION OF THIS INVESTIGATION WILL PROVIDE RESEARCHERS WITH A RAPID, ACCURATE, AND RELIABLE INSTRUMENT TO MEASURE OVERALL DECOMPOSITION RATES WITHOUT APPLYING A PHYSICAL OR CHEMICAL STRESS (E.G., DISSOLUTION, HEATING, CHANGES IN IONIC STRENGTH, ETC.). THUS, NEW INSIGHTS INTO THE DEGRADATION PROCESS WILL BE ACHIEVED.

* information listed above is at the time of submission.

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